Cornus officinalis, theJapanese cornel orJapanese cornelian cherry,[1] is aspecies offlowering plant in the dogwoodfamily Cornaceae. Despite its name, it isnative to China and Korea as well as Japan.[2] It is not to be confused withC. mas, which is also known as the Cornelian cherry. It is not closely related to the truecherries of the genusPrunus.
It is a large, strongly-growingdeciduous shrub with rough flaky bark. Umbels of acid yellow flowers appear in early spring before the oval leaves. The red berries, which are edible, appear later in the summer, and the leaves turn shades of red before falling in the autumn.[3]
The plant is valued in cultivation for providing year-round interest in the garden. It is, however, quite a substantial shrub, typically growing to 8 m (26 ft) tall and broad. Thecultivar 'Kintoki', with larger and more abundant flowers, has won theRoyal Horticultural Society'sAward of Garden Merit.[5][6]
Ethanolic extracts of the fruit ofC. officinalis has been shown to prevent hepatic injuries associated withacetaminophen-induced liver injury-inducedhepatotoxicity (in mice) by preventing or alleviating oxidative stress.[9]
The chemical constituents isolated from the fruit (Corni fructus) have protective effects onbeta cellsin vitro,[10][11] and may control postprandial hyperglycemia byalpha-glucosidase inhibition.[12]
Cornel iridoid glycoside, a chemical extracted fromCornus officinalis, promotedneurogenesis andangiogenesis and improved neurological function afterischemia in rats.[13]
Morroniside, the most abundant iridoid glycoside extracted fromCornus officinalis, substantially reduces osteophyte formation and subchondral sclerosis in mice models. Specifically, morroniside significantly promotes cartilage matrix synthesis by increasing collagen type II expression and suppressing chondrocyte pyroptosis. It inhibits matrix metalloproteinase-13 (MMP13), Caspase-1 and nod-like receptor protein-3 (NLRP3) expression in DMM mice and IL-1β-stimulated chondrocytes, and enhances chondrocyte proliferation and inhibits chondrocyte apoptosis.[14] It also slows OA progression by inhibiting nuclear factor-κB (NF-κB) signaling.[15]
A randomized, double-blinded, placebo-controlled study found that a Chinese herbal formula that mainly consisted ofCornus officinalis was not only effective at improving erectile function, but it was also safe for the treatment of erectile dysfunction.[16] A chemical substance isolated fromCornus officinalis also may enhance the motility of human sperm.[17]
Corneliancherry juices are rich in potassium, calcium, sodium, iron, zinc, manganese, and copper. Compared to other juices obtained from plum, pear, and apple, Cornelian cherry juice contained higher levels of dietary minerals.[19]
^"AGM Plants - Ornamental"(PDF).www.rhs.org. Royal Horticultural Society. July 2017. p. 107. Retrieved8 February 2020.
^Wang, R; Wang, SM; Liang, SW; Xu, GW; Weng, QF (August 2007)."胶束电动毛细管色谱法分离分析山茱萸中齐墩果酸和熊果酸" [Separation and determination of oleanolic acid and ursolic acid from Cornus officinalis by capillary electrophoresis].Journal of Chinese Medicinal Materials (in Chinese).30 (8):946–50.PMID18074841.
^Yu, Hyeon-Hee; Hur, Jong-Moon; Seo, Se-Jeong; Moon, Hae-Dalma; Kim, Hyun-Jin; Park, Rae-Kil; You, Yong-Ouk (January 2009). "Protective Effect of Ursolic Acid from Cornus officinalis on the Hydrogen Peroxide-Induced Damage of HEI-OC1 Auditory Cells".The American Journal of Chinese Medicine.37 (4):735–746.doi:10.1142/S0192415X0900720X.PMID19655411.
^Lin, Mei-Hsiang; Liu, Hui-Kang; Huang, Wei-Jan; Huang, Chu-Chun; Wu, Tzu-Hua; Hsu, Fen-Lin (27 July 2011). "Evaluation of the Potential Hypoglycemic and Beta-Cell Protective Constituents Isolated from Corni Fructus To Tackle Insulin-Dependent Diabetes Mellitus".Journal of Agricultural and Food Chemistry.59 (14):7743–7751.doi:10.1021/jf201189r.PMID21682333.
^Park, Chan Hum; Noh, Jeong Sook; Tanaka, Takashi; Cho, Eun Ju; Yokozawa, Takako (1 May 2009). "Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent".Journal of Pharmacy and Pharmacology.61 (5):653–661.doi:10.1211/jpp/61.05.0015.PMID19406005.
^Park, Chan Hum; Noh, Jeong Sook; Tanaka, Takashi; Uebaba, Kazuo; Cho, Eun Ju; Yokozawa, Takako (January 2011). "The Effects of Corni Fructus Extract and Its Fractions Against α-Glucosidase Inhibitory Activities in Vitro and Sucrose Tolerance in Normal Rats".The American Journal of Chinese Medicine.39 (2):367–380.doi:10.1142/S0192415X11008889.PMID21476212.
^Yao, R. -Q.; Zhang, L.; Wang, W.; Li, L. (6 April 2009). "Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats".Brain Research Bulletin.79 (1):69–76.doi:10.1016/j.brainresbull.2008.12.010.PMID19150488.S2CID206340102.
^Yu, Huan; Yao, Sai; Zhou, Chengchong; Fu, Fangda; Luo, Huan; Du, Weibin; Jin, Hongting; Tong, Peijian; Chen, Di; Wu, Chengliang; Ruan, Hongfeng (February 2021). "Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling".Journal of Ethnopharmacology.266: 113447.doi:10.1016/j.jep.2020.113447.PMID33022338.S2CID222183646.
^Kam, Sung-Chul; Choi, See-Min; Jeh, Sung-Uk; Lee, Seung-Hyun; Hwa, Jeong-Seok; Jung, Ky-Hyun; Kang, Chang-Wan; Hyun, Jae-Seog (2007)."산수유 복합 추출 분말이 발기 부전증 환자에 미치는 임상적 효과와 안전성" [Efficacy and Safety of a Herbal Formula that Mainly Consists of Cornus Officinalis for Erectile Dysfunction: A Double-blind, Placebo-controlled Study].Investigative and Clinical Urology (in Korean).48 (7):741–747.
^Jeng, Hellen; Wu, Chao Mei; Su, Shuen-Jiing; Chang, Wen-Chang (January 1997). "A Substance Isolated from Cornus officinalis Enhances the Motility of Human Sperm".The American Journal of Chinese Medicine.25 (3n04):301–306.doi:10.1142/S0192415X97000330.PMID9358903.
