Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is ananaphylatoxin that possesses potentspasmogenic andchemotactic activity, is derived from the alpha polypeptide via cleavage with aC5-convertase. The C5b macromolecular cleavage product can form a complex with theC6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.[5]
Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility toliver fibrosis and torheumatoid arthritis.[5]
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