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| Clinical data | |
|---|---|
| Trade names | Colestid, Cholestabyl |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682157 |
| Routes of administration | Oral (suspension or tablets) |
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| Pharmacokinetic data | |
| Bioavailability | None |
| Excretion | Faeces, in complex withbile acids |
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| DrugBank |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.123.044 |
| Chemical and physical data | |
| Formula | (C4H10N3)m(C3H6O)n |
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Colestipol (trade namesColestid,Cholestabyl) is abile acid sequestrant used to lower bloodcholesterol, specificallylow-density lipoprotein (LDL).[1][2] It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.[3]
Likecholestyramine, colestipol works in the gut by trappingbile acids and preventing them from being reabsorbed. This leads to decreasedenterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increasedLDL receptor expression, and decreasing LDL in blood.[4]
The following notable side effects may occur:[2]
Colestipol can bind to a number of drugs and nutrients in the gut and inhibit or delay their absorption. Such substances include:[2]
Colestipol is contraindicated inhypertriglyceridemia (high level oftriglycerides in the blood).[citation needed]
Colestipol is acopolymer ofdiethylenetriamine (DETA) —ortetraethylenepentamine according to some sources[5][6]— andepichlorohydrin.[7][8] The structure drawing (top right) shows the DETA moieties in blue and the epichlorohydrin moieties in red.
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