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| Combination of | |
|---|---|
| Codeine | Opioidanalgesic |
| Paracetamol | Anilide analgesic |
| Clinical data | |
| Trade names | Tylenol with codeine Zapain Panadeine Forte |
| MedlinePlus | a601005 |
| License data | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChemCID | |
| ChemSpider |
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| KEGG | |
 N Y (what is this?) (verify) | |
Codeine/paracetamol, also calledcodeine/acetaminophen andco-codamol, is acompound analgesic, comprisingcodeine phosphate andparacetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderatepain when paracetamol ornon-steroidal anti-inflammatory drugs (NSAIDs; such asibuprofen,aspirin, andnaproxen) alone do not sufficiently relieve symptoms.[2][3]
In 2023, it was the 210th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[7][8]
The most common side effects include constipation, nausea and drowsiness.[9]Others includecoughing up blood from the lungs,skin rashes,dizziness,sedation, shortness of breath,hypersensitivity reaction,fainting (syncope or near syncope),confusion, loss ofshort-term memory, changes inblood, allergic reactions,euphoria,dysphoria, abdominal pain, itchiness, easybruising, bleedinggums,vivid dreams, dry mouth and addiction.[10]
Genetic differences between people cause differing rates of metabolism of codeine tomorphine. In about 5 percent of people this may happen particularly fast, causing morphine to be passed through breast milk in amounts that may cause fatalrespiratory depression in a breastfed baby.[11]
Of the European Union member states, eleven allowover-the-counter sale of solid dosage forms of codeine, including codeine/paracetamol: Bulgaria, Cyprus, Denmark, France, Ireland, Latvia, Lithuania, Malta, Poland, Romania, and Slovenia.[12]
| pyrazolones / pyrazolidines | |
|---|---|
| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
