Clonixin

Names
Preferred IUPAC name 2-(3-Chloro-2-methylanilino)pyridine-3-carboxylic acid
Other names Clonixic acid; CBA 93626[1]
Identifiers
CAS Number	17737-65-4 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:76200 N[???]
ChEMBL	ChEMBL1332971 N
ChemSpider	26711 N
ECHA InfoCard	100.037.921
KEGG	D03555 Y
PubChemCID	28718
UNII	V7DXN0M42R Y
CompTox Dashboard(EPA)	DTXSID2046121
InChI InChI=1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18) N Key: CLOMYZFHNHFSIQ-UHFFFAOYSA-N N InChI=1/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18) Key: CLOMYZFHNHFSIQ-UHFFFAOYAG
SMILES O=C(O)C1=CC=CN=C1NC2=C(C)C(Cl)=CC=C2
Properties
Chemical formula	C13H11ClN2O2
Molar mass	262.69 g·mol−1
Pharmacology
Routes of administration	per os
Pharmacokinetics:
Metabolism	Glucuronidation via UGT2B7
Legal status	US: Not sold in the U.S.
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Clonixin is anonsteroidal anti-inflammatory drug (NSAID). It also hasanalgesic,antipyretic, andplatelet-inhibitory actions. It is used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.

The glyceryl ester of clonixin, clonixeril, is also an NSAID. It was prepared by a somewhat roundabout method.

Clonixin was reacted withchloroacetonitrile andtriethylamine to give2. Heating withpotassium carbonate andglycerol acetonide displaced theactivating group to produce ester3, which was deblocked inacetic acid to produce clonixeril (4).

• Flunixin

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