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| Clinical data | |
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| Trade names | Senioral (withPPATooltip phenylpropanolamine) |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth |
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| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| ChemSpider | |
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| Chemical and physical data | |
| Formula | C26H27ClN2 |
| Molar mass | 402.97 g·mol−1 |
| 3D model (JSmol) | |
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Clocinizine is afirst-generation antihistamine of thediphenylmethylpiperazine class. It is marketed inSpain incombination withphenylpropanolamine under the brand nameSenioral.[1]
The reduction of 4-Chlorobenzophenone [134-85-0] (1) with NBH gives 4-Chlorobenzhydrol [119-56-2] (2). Halogenation of the alcohol in muriatic acid afforded 4-Chlorobenzhydryl chloride [134-83-8] (3). Alkylation with one equivalent of piperazine gives 1-(4-Chlorobenzhydryl)piperazine [303-26-4] (4). Alkylation of the remaining nitrogen with Cinnamyl Bromide [4392-24-9] (5) completed the synthesis of Clocinizine (6).