American geneticist
Clifford James Tabin (born 1954)[ 8] Harvard Medical School .[ 9] [ 10]
Tabin was educated at theUniversity of Chicago where he was awarded aBS in physics in 1976.[ 9] graduate school atMassachusetts Institute of Technology and was awarded aPhD in 1984 for work on theregulation of gene expression in theRas subfamily ofoncogenes supervised byRobert Weinberg based in theMIT Department of Biology .[ 11] murine leukemia virus ,[ 12] eukaryotic vector .[ 10]
Following his PhD, Tabin didpostdoctoral research withDouglas A. Melton atHarvard University , then moved toMassachusetts General Hospital where he worked on the molecular biology of limb development. He was appointed to the faculty in the Department of Genetics at Harvard Medical School in 1989, and promoted to full professor in 1997 and chairman of the department in January 2007.[ 13] [ 14]
As of 2014[update] [ 15] [ 16] [ 17] [ 18] [ 19] [ 20] embryology with modern molecular and genetic techniques for regulatinggene expression duringembryogenesis .[ 21] [ 22] [ 23]
Previously Tabin has worked onretroviruses ,homeobox genes, oncogenes,developmental biology andevolution . Early in his research he investigated limb regeneration in thesalamander , and described the expression ofretinoic acid receptor andHox genes in theblastema . Comparative studies by Ann Burke[ 24] [ 25] Hox gene expression correlated with differences in skeletal morphology.[ 5] [ 26] [ 27] [ 28] Connie Cepko .[ 29]
Tabin was elected aForeign Member of the Royal Society (ForMemRS) in 2014. His nomination reads:
Tabin has made fundamental discoveries on embryonic development and evolution. A critical turning point in the history of developmental biology was the identification of the first known secretedmorphogen ,Sonic hedgehog . He clarified how morphogens likeShh orchestrate formation of theembryo , elucidating why the heart is located on the left and not the right side of the body and explaining why the thumb is different from the little finger. This provided critical insight into the origins of humancongenital malformations . He has also solved important evolutionary riddles including the causes of variations in beak shape inDarwin's finches .[ 1]
Tabin has also been awarded theEdwin Conklin Medal in 2012,[ 2] March of Dimes Prize in Developmental Biology jointly withPhilip A. Beachy in 2008[ 3] NAS Award in Molecular Biology in 1999. He was elected a member of theNational Academy of Sciences in 2007[ 4] American Academy of Arts and Sciences in 2000. He was elected a Member of theAmerican Philosophical Society in 2019.
Tabin is the son of Julius Tabin,[ 9] [ 10] [ 30] Enrico Fermi on theManhattan Project inLos Alamos National Laboratory in New Mexico during World War II. He has a brother,Geoff Tabin , and two children. Tabin appears as himself in aBBC Horizon programme titledHopeful Monsters .[ 31]
^a b "Professor Clifford Tabin ForMemRS" . London: The Royal Society. Archived fromthe original on May 2, 2014.^a b Clifford Tabin Awarded Conklin Medal ,Society for Developmental Biology ^a b Anon (2008). "An Interview With... Cliff Tabin".Nature Reviews Genetics .9 (6): 420.doi :10.1038/nrg2863 .PMID 18504824 .S2CID 45619315 . ^a b "Clifford J. Tabin, Harvard University" . National Academy of Sciences. Archived fromthe original on October 14, 2014.^a b Patrick Goymer (April 2006)."Milestone 17: (1979) First human oncogene: An important difference" .Nature Reviews Cancer .6 . Nature: S18.doi :10.1038/nrc1859 . ^ Marigo, V.; Davey, R. A.; Zuo, Y.; Cunningham, J. M.; Tabin, C. J. (1996). "Biochemical evidence that Patched is the Hedgehog receptor".Nature .384 (6605):176– 9.Bibcode :1996Natur.384..176M .doi :10.1038/384176a0 .PMID 8906794 .S2CID 4325188 . ^ Riddle, R. D.; Johnson, R. L.; Laufer, E.; Tabin, C. (1993). "Sonic hedgehog mediates the polarizing activity of the ZPA".Cell .75 (7):1401– 16.doi :10.1016/0092-8674(93)90626-2 .PMID 8269518 .S2CID 4973500 . ^ Cliff Tabin Archived 2016-03-04 at theWayback Machine , Harvard Medical School^a b c Mossman, K. (2009)."Profile of Clifford Tabin" .Proceedings of the National Academy of Sciences .106 (21):8407– 8409.Bibcode :2009PNAS..106.8407M .doi :10.1073/pnas.0903946106 PMC 2688980 PMID 19458049 . ^a b c Tabin, C (2009)."Molecular tools, classic questions - an interview with Clifford Tabin. Interviewed by Richardson, Michael K" .The International Journal of Developmental Biology .53 (5– 6):725– 31.doi :10.1387/ijdb.072575mr PMID 19557679 . ^ Tabin, Clifford James (1984).Activation of the c-Ha-ras Oncogene (PhD thesis). Massachusetts Institute of Technology.OCLC 13089293 . ^ Goff, S. P.;Tabin, C. J. ; Wang, J. Y.;Weinberg, R ;Baltimore, D (1982)."Transfection of fibroblasts by cloned Abelson murine leukemia virus DNA and recovery of transmissible virus by recombination with helper virus" .Journal of Virology .41 (1):271– 85.doi :10.1128/JVI.41.1.271-285.1982 .PMC 256749 PMID 6283119 . ^ Cliff Tabin molbio seminar ,Princeton University ^ Harfe, B. D.; McManus, M. T.; Mansfield, J. H.; Hornstein, E.; Tabin, C. J. (2005)."The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb" .Proceedings of the National Academy of Sciences .102 (31):10898– 903.Bibcode :2005PNAS..10210898H .doi :10.1073/pnas.0504834102 PMC 1182454 PMID 16040801 . ^ Clifford Tabin's publications indexed by theScopus bibliographic database.(subscription required) ^ Clifford Tabin publications indexed byMicrosoft Academic ^ Clifford Tabin publications ,Google Scholar ^ Parada, L. F.; Tabin, C. J.; Shih, C.; Weinberg, R. A. (1982). "Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene".Nature .297 (5866):474– 8.Bibcode :1982Natur.297..474P .doi :10.1038/297474a0 .PMID 6283357 .S2CID 4338225 . ^ Marigo, V.; Davey, R. A.; Zuo, Y.; Cunningham, J. M.; Tabin, C. J. (1996). "Biochemical evidence that Patched is the Hedgehog receptor".Nature .384 (6605):176– 9.Bibcode :1996Natur.384..176M .doi :10.1038/384176a0 .PMID 8906794 .S2CID 4325188 . ^ McMahon, A. P.; Ingham, P. W.; Tabin, C. J. (2003). "1 Developmental roles and clinical significance of Hedgehog signaling".Current Topics in Developmental Biology .53 :1– 114.doi :10.1016/S0070-2153(03)53002-2 .ISBN 9780121531539 PMID 12509125 . ^ Tabin, C. J. (1991). "Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development".Cell .66 (2):199– 217.doi :10.1016/0092-8674(91)90612-3 .PMID 1677315 .S2CID 5269260 . ^ Johnson, R. L.; Tabin, C. J. (1997)."Molecular models for vertebrate limb development" .Cell .90 (6):979– 90.doi :10.1016/s0092-8674(00)80364-5 PMID 9323126 .S2CID 16213729 . ^ Vortkamp, A.; Lee, K.; Lanske, B.; Segre, G. V.; Kronenberg, H. M.; Tabin, C. J. (1996). "Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein".Science .273 (5275):613– 22.Bibcode :1996Sci...273..613V .doi :10.1126/science.273.5275.613 .PMID 8662546 .S2CID 27737023 . ^ Burke, A. C.; Nelson, C. E.; Morgan, B. A.; Tabin, C (1995). "Hox genes and the evolution of vertebrate axial morphology".Development .121 (2):333– 46.doi :10.1242/dev.121.2.333 .PMID 7768176 . ^ Burke, A. C.; Tabin, C. J. (1996)."Virally mediated misexpression of Hoxc-6 in the cervical mesoderm results in spinal nerve truncations" .Developmental Biology .178 (1):192– 7.doi :10.1006/dbio.1996.0210 PMID 8812121 . ^ Morgan, B. A.; Tabin, C. J. (1993). "The role of homeobox genes in limb development".Current Opinion in Genetics & Development .3 (4):668– 74.doi :10.1016/0959-437x(93)90105-x .PMID 7902151 . ^ Tabin, C. J. (2006)."The Key to Left-Right Asymmetry" .Cell .127 (1):27– 32.doi :10.1016/j.cell.2006.09.018 PMID 17018270 .S2CID 1775936 . ^ Logan, M; Pagán-Westphal, S. M.; Smith, D. M.; Paganessi, L;Tabin, C. J. (1998)."The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals" .Cell .94 (3):307– 17.doi :10.1016/S0092-8674(00)81474-9 PMID 9708733 .S2CID 14375165 . ^ Profile of Constance L. Cepko, Ph.D , BioTechniques Vol. 36, No. 5, 2004-05-05, p. 737^ Julius Tabin Obituary (1919-2012) Physicist helped develop atom bomb ,Chicago Tribune , 2012-09-02^ Clifford Tabin atIMDb
International National Academics
