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Clifford P. Brangwynne | |
|---|---|
| Born | (1978-04-24)April 24, 1978 (age 47) Boston, Massachusetts, USA |
| Alma mater | Carnegie Mellon UniversityHarvard University |
| Scientific career | |
| Fields | Soft-matter physics,cell biology |
| Institutions | Princeton University |
Clifford P. Brangwynne is an Americanbioengineer,biophysicist and pioneer in the study ofbiomolecular condensates. Brangwynne is a professor of chemical and biological engineering atPrinceton University, the director of the Omenn-Darling Bioengineering Institute, and the June K. Wu ’92 Professor in Engineering[1]. He is also a researcher at theHoward Hughes Medical Institute.[2]
Brangwynne graduated fromCarnegie Mellon University in 2001 with a degree in materials science and engineering, and received his Ph.D. in applied physics fromHarvard University in 2007.[3] He served as a postdoctoral fellow from 2007 to 2010 at theMax Planck Institute of Molecular Cell Biology and Genetics, working with his adviserAnthony Hyman.[4]
In 2009, Brangwynne discovered that cellular structures known as P granulesdissolved andcondensed in their surroundingcytoplasm through a process of liquid-liquidphase separation, with no confiningmembrane, overturning long-held assumptions about the nature oforganelles.[5] In 2012, liquid-liquid phase separation was linked to neurodegenerative diseases such as ALS and Alzheimer’s. In 2017, it was linked to gene regulation.[6]
Brangwynne joined the Princeton faculty in 2011 as an assistant professor of chemical and biological engineering. At the time he was hired, the P granules paper had fewer than 10 citations; it has since accumulated more than 3,300[7]. He was promoted to associate professor in 2017 and to full professor in 2019. In 2020, he was named the June K. Wu ’92 Professor of Chemical and Biological Engineering and director of the Princeton Bioengineering Initiative, renamed the Omenn-Darling Bioengineering Institute in 2023.[4]
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