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Clidinium bromide

From Wikipedia, the free encyclopedia
Anticholinergic, muscarinic antagonist drug
Not to be confused withAcridinium bromide orAclidinium bromide.
Pharmaceutical compound
Clidinium bromide
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa601036
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityLow
ExcretionRenal and biliary
Identifiers
  • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H26NO3+
Molar mass352.454 g·mol−1
3D model (JSmol)
  • O=C(OC2C1CC[N+](CC1)(C)C2)C(O)(c3ccccc3)c4ccccc4
  • InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1 checkY
  • Key:HOOSGZJRQIVJSZ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Clidinium bromide (INN) is ananticholinergic (specifically amuscarinic antagonist)drug.[1][2] It may help symptoms of cramping and abdominal/stomach pain by decreasingstomach acid, and slowing the intestines. It is commonly prescribed in combination withchlordiazepoxide (abenzodiazepine derivative) using the brand nameLibrax,Normaxin CC.

Uses

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Peptic ulcer disease

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Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.[3]

With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.

GI motility disturbances

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Used in fixed combination with chlordiazepoxide in the treatment of functional GI motility disturbances (e.g., irritable bowel syndrome).

Has limited efficacy in treatment of GI motility disturbance and should only be used if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.

Acute enterocolitis

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Used in fixed combination withchlordiazepoxide in the treatment of acuteenterocolitis. However,antimuscarinics should be used with extreme caution in patients with diarrhea orulcerative colitis.

Mechanism of action

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Clidinium inhibitsmuscarinic acetylcholine receptors onsmooth muscles,secretory glands, and in thecentral nervous system to relaxsmooth muscle and decreasebiliary tract secretions.[4] It is said to be aselectivemuscarinic acetylcholineM3 receptorantagonist.[5]

References

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  1. ^"Clidinium bromide". Drugs.com. RetrievedAugust 24, 2013.
  2. ^Aronson JK (2016)."Clidinium bromide".Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions (Sixteenth ed.). Amsterdam: Elsevier. p. 404.ISBN 978-0-444-53716-4.
  3. ^"Clidinium Bromide Monograph". Drugs.com. RetrievedAugust 24, 2013.
  4. ^"Clidinium bromide".2014 Nurse's Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2013. pp. 245–246.ISBN 978-1-284-03115-7.
  5. ^Lavrador M, Cabral AC, Veríssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM (January 2023)."A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity".Pharmaceutics.15 (1): 230.doi:10.3390/pharmaceutics15010230.PMC 9863833.PMID 36678858.

External links

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mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)
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