In 1906 he noticed that patients who had previously received injections of horse serum orsmallpox vaccine had quicker, more severe reactions to a second injection. He coined the wordallergy (from the Greekallos meaning "other" andergon meaning "work") to describe thishypersensitivity reaction.[2]
Soon after, the observation with smallpox led Pirquet to realize thattuberculin, whichRobert Koch isolated from thebacteria that causetuberculosis in 1890, might lead to a similar type of reaction.Charles Mantoux expanded upon Pirquet's ideas and theMantoux test, in which tuberculin is injected into the skin, became a diagnostic test for tuberculosis in 1907.
In 1909 he declined proposals to take a position at thePasteur Institute in Paris and to become a professor at theJohns Hopkins University. In 1910 he returned to Europe taking positions inBreslau (now Wrocław) and then Vienna.
^Regarding personal names:Freiherr is a former title (translated as'Baron'). In Germany since 1919, it forms part of family names. The feminine forms areFreifrau andFreiin.
^von Pirquet, Clemens (1906). "Allergie".Münchener medizinische Wochenschrift.
Bergmann, K C (2006), "[Clemens Freiherr von Pirquet, developer of the concept of allergy]",MMW Fortschritte der Medizin, vol. 148, no. 29–30 (published Jul 20, 2006), pp. 24–5, 27,PMID16910402
Bukantz, Samuel C (2002), "Clemens von Pirquet and the concept of allergie",J. Allergy Clin. Immunol., vol. 109, no. 4 (published Apr 2002), pp. 724–6,doi:10.1067/mai.2002.123049,PMID11980437
Slavin, R G (1982), "The 10th annual Clemens von Pirquet lectureship. Clinical disorders of the nose and their relationship to allergy",Annals of Allergy, vol. 49, no. 3 (published Sep 1982), pp. 123–6,PMID7051906
Bendiner, E (1981), "Baron von Pirquet: the aristocrat who discovered and defined allergy",Hosp. Pract. (Off. Ed.), vol. 16, no. 10 (published Oct 1981), pp. 137, 141, 144 passim,PMID6800919
Wyklicky, H (1980), "[Thoughts on the history of allergy. In memoriam Clemens von Pirquet]",Wiener Medizinische Wochenschrift, vol. 130, no. 3 (published Feb 15, 1980), pp. 123–5,PMID6989119
Kapus, G (1979), "[In memory of Clemens v. Pirquet]",Orvosi Hetilap, vol. 120, no. 22 (published Jun 3, 1979), pp. 1327–30,PMID379734
Asperger, H (1979), "[50th anniversary of the death of Clemens von Pirquet]",Pädiatrie und Pädologie, vol. 14, no. 2, pp. I–II,PMID379746
"[Münchener Medizinische Wochenschrift/24 July 1906: Allergy by Clemens v. Pirquet, Vienna]",MMW, Münchener Medizinische Wochenschrift, vol. 120, no. 14 (published Apr 7, 1978), p. 474, 1978,PMID347265
Székely, S (1974), "[Clemens von Pirquet]",Orvosi Hetilap, vol. 115, no. 20 (published May 19, 1974), pp. 1175–7,PMID4597514
Rapaport, H G (1973), "Clemens von Pirquet and allergy",Annals of Allergy, vol. 31, no. 10 (published Oct 1973), pp. 467–75,PMID4588535
TREIMAN, V V (1965), "Clemens Pirquet, an Outstanding Austrian Man of Medicine",Sovetskaia Meditsina, vol. 28 (published Mar 1965), pp. 151–3,PMID14290647
WAGNER, R (1964), "Clemens von Pirquet, Discoverer of the Concept of Allergy",Bulletin of the New York Academy of Medicine, vol. 40, no. 3 (published Mar 1964), pp. 229–35,PMC1750523,PMID14130490
WAGNER, R (1963), "[Clemens von PIRQUET.]",Wien. Klin. Wochenschr., vol. 75 (published Apr 5, 1963), pp. 241–3,PMID13998265
KUNDRATITZ, K (1954), "[Researches and theories of Clemens von Pirquet.]",Wien. Klin. Wochenschr., vol. 66, no. 13 (published Apr 2, 1954), pp. 217–20,PMID13169763