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Cinolazepam

From Wikipedia, the free encyclopedia
Chemical compound
Not to be confused withcinazepam,clonazepam, orcamazepam.
Pharmaceutical compound
Cinolazepam
Small white round pill with a line in the middle on one side, thin with nothing on the other side
Clinical data
Trade namesGerodorm 40mg
AHFS/Drugs.comcinolazepam
Dependence
liability
High
Addiction
liability
Medium
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability90–100%
MetabolismHepatic
Onset of action30 minutes to 1 hour
Eliminationhalf-life9 hours
Duration of action9 hours
ExcretionRenal
Identifiers
  • (RS)-3-[9-Chloro-6-(2-fluorophenyl)-4-hydroxy-3-oxo-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-2-yl]propanenitrile
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC18H13ClFN3O2
Molar mass357.77 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • FC1=CC=CC=C1C2=NC(C(N(CCC#N)C3=C2C=C(C=C3)Cl)=O)O
  • InChI=1S/C18H13ClFN3O2/c19-11-6-7-15-13(10-11)16(12-4-1-2-5-14(12)20)22-17(24)18(25)23(15)9-3-8-21/h1-2,4-7,10,17,24H,3,9H2 checkY
  • Key:XAXMYHMKTCNRRZ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cinolazepam[1] (marketed under the brand nameGerodorm)[2] is a drug which is abenzodiazepine derivative. It possessesanxiolytic,anticonvulsant,sedative andskeletal muscle relaxant properties.Due to its strong sedative properties, it is primarily used as ahypnotic.

It was patented in 1978 and came into medical use in 1992.[3] Cinolazepam is mainly used in Romania and Slovakia; it not approved for sale in the United States or Canada.

References

[edit]
  1. ^ US Patent 4388313 Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof
  2. ^Lannacher Romania (1999)."Gerodorm".Produse Gerot inregistrate in Romania (in Romanian). Archived fromthe original on 11 October 2006. Retrieved17 August 2006.
  3. ^Fischer J, Ganellin CR (2006).Analogue-based Drug Discovery. John Wiley & Sons. p. 530.ISBN 9783527607495.

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