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Chronotherapy, also calledchronotherapeutics[1] orchronotherapeutic drug delivery,[2] refers to the coordination of therapeutic treatments with an individual'scircadian or other rhythmic cycles. This may be done to maximize effectiveness of a specific treatment, minimize possible side effects, or both.[3][4]
In the treatment of psychiatric conditions includingbipolar depression,[5][6] a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.[7][8][9]
^Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (December 2005). "Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates".The Journal of Clinical Psychiatry.66 (12):1535–40.doi:10.4088/jcp.v66n1207.PMID16401154.
^Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C (February 2014). "Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression".The Journal of Clinical Psychiatry.75 (2):133–40.doi:10.4088/JCP.13m08455.PMID24345382.
^Benedetti F, Barbini B, Colombo C, Smeraldi E (December 2007). "Chronotherapeutics in a psychiatric ward".Sleep Medicine Reviews.11 (6):509–22.doi:10.1016/j.smrv.2007.06.004.PMID17689120.
