| Chronic traumatic encephalopathy | |
|---|---|
| Other names | Traumatic encephalopathy syndrome, dementia pugilistica,[1] punch drunk syndrome |
 | |
| A normal brain (left) and one with advanced CTE (right) | |
| Specialty | Neurology,psychiatry,sports medicine |
| Symptoms | Behavioral problems,mood problems, problems with thinking[1] |
| Complications | Brain damage,dementia,[2]aggression,depression,suicide[3] |
| Usual onset | Years after initial injuries[2] |
| Causes | Repeatedhead injuries[1] |
| Risk factors | Contact sports,military service, repeated banging of the head[1] |
| Diagnostic method | Autopsy[1] |
| Differential diagnosis | Alzheimer's disease,Parkinson's disease[3] |
| Treatment | Supportive care[3] |
| Prognosis | Worsens over time[2] |
| Frequency | Uncertain[2] |
Chronic traumatic encephalopathy (CTE) is aneurodegenerative disease linked to repeated trauma to the head. Theencephalopathy symptoms can include behavioral problems,mood problems, and problems with thinking.[1][4] The disease often gets worse over time and can result indementia.[2]
Most documented cases have occurred in athletes involved instriking-basedcombat sports, such asboxing,kickboxing,mixed martial arts, andcontact sports such asrugby union,rugby league,gridiron football,Australian rules football,professional wrestling, andice hockey. It is also an issue inassociation football, but largely as a result ofheading the ball rather than player contact.[1][5] Other risk factors include being in the military (combat arms), priordomestic violence, and repeated banging of the head.[1] The exact amount of trauma required for the condition to occur is unknown, and as of 2025 definitive diagnosis can only occur atautopsy.[1] The disease is classified as atauopathy.[1]
There is no specific treatment for the disease.[3] Rates of CTE have been found to be about 30% among those with a history of multiple head injuries;[1] however, population rates are unclear.[2] Research in brain damage as a result of repeated head injuries began in the 1920s, at which time the condition was known asdementia pugilistica or "boxer's dementia", "boxer's madness", or "punch drunk syndrome".[1][3] It has been proposed that the rules of some sports be changed as a means of prevention.[1]
Symptoms of CTE, which occur in four stages, generally appear eight to ten years after an individual experiences repetitive mild traumatic brain injuries.[6]
First-stage symptoms areconfusion,disorientation,dizziness, andheadaches. Second-stage symptoms includememory loss, social instability,impulsive behavior, and poor judgment. Third and fourth stages include progressivedementia,movement disorders,hypomimia,speech impediments,sensory processing disorder,tremors,vertigo,deafness,depression andsuicidality.[7]
Additional symptoms includedysarthria,dysphagia,cognitive disorders such asamnesia, and ocular abnormalities, such asptosis.[8] The condition manifests asdementia, or declining mental ability, problems with memory, dizzy spells or lack of balance to the point of not being able to walk under one's own power for a short time and/orParkinsonism, ortremors and lack of coordination. It can also causespeech problems and an unsteadygait. Patients with CTE may be prone to inappropriate or explosive behavior and may displaypathological jealousy orparanoia.[9]
Most documented cases have occurred in athletes with mild repetitive head impacts (RHI) over an extended period. Evidence indicates that repetitive concussive and subconcussive blows to the head cause CTE.[10] In particular, it is associated withcontact sports such asboxing,American football,Australian rules football,wrestling,mixed martial arts,ice hockey,rugby, andassociation football.[1][5] In association football, whether this is just associated with prolificheaders or other injuries is unclear as of 2017.[11] Other potential risk factors include military personnel (repeated exposure to explosive charges or large caliber ordnance),domestic violence, and repeated impact to the head.[1] Although many military personnel are around blasts and explosions very often, it is very rare for these personnel to be diagnosed with CTE. Studies have shown that only 4.4% of deceased military veterans have been diagnosed with CTE.[12] Exposure to blasts from explosives can produce symptoms of CTE.[13] Another cause of CTE is an excessive buildup of misfolded Tau proteins, which set off a reaction that slowly kills the brain cells.[14] The exact amount of trauma required for the condition to occur is unknown, although it is believed that it may take years to develop.[1]
Theneuropathological appearance of CTE is distinguished from othertauopathies, such asAlzheimer's disease. The four clinical stages of observable CTE disability have been correlated with tau pathology in brain tissue, ranging in severity from focal perivascular epicenters of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions.[15]
The primary physical manifestations of CTE include a reduction in brain weight, associated with atrophy of the frontal and temporal cortices andmedial temporal lobe. The lateralventricles and thethird ventricle are often enlarged, with rare instances of dilation of thefourth ventricle.[16] Other physical manifestations of CTE include anteriorcavum septi pellucidi and posteriorfenestrations, pallor of thesubstantia nigra andlocus ceruleus, and atrophy of theolfactory bulbs,thalamus,mammillary bodies,brainstem andcerebellum.[17] As CTE progresses, there may be marked atrophy of thehippocampus,entorhinal cortex, andamygdala.[6]
On a microscopic scale, a pathognomonic CTE lesion involves p-tau aggregates in neurons, with or without thorn-shapedastrocytes, at the depths of the cortical sulcus around a small blood vessel, deep in the parenchyma, and not restricted to the subpial and superficial region of the sulcus; the pathognomonic lesion must include p-tau in neurons to distinguish CTE fromaging-related tau astrogliopathy (ARTAG).[18] Supporting features of CTE are: superficialneurofibrillary tangles (NFTs); p–tau in CA2 and CA4 hippocampus; p-tau in: mammillary bodies, hypothalamic nuclei, amygdala, nucleus accumbens, thalamus, midbrain tegmentum, nucleus basalis of Meynert, raphe nuclei, substantia nigra and locus coeruleus; p-tau thorn-shaped astrocytes (TSA) in the subpial region; p-tau dot-likeneurites.[19] Purely astrocytic perivascular p-tau pathology represents ARTAG and does not meet the criteria for CTE.[18]
A small group of individuals with CTE have chronic traumatic encephalomyopathy (CTEM), which is characterized by symptoms of motor-neuron disease and which mimicsamyotrophic lateral sclerosis (ALS). Progressive muscle weakness and balance and gait problems (problems with walking) seem to be early signs of CTEM.[16]
Exosome vesicles created by the brain are potential biomarkers of TBI, including CTE.[20]
Loss ofneurons, scarring of brain tissue, collection ofproteinaceous senile plaques,hydrocephalus, attenuation of thecorpus callosum,diffuse axonal injury,neurofibrillary tangles, and damage to thecerebellum are implicated in the syndrome. Neurofibrillary tangles have been found in the brains of dementia pugilistica patients, but not in the same distribution as is usually found in people with Alzheimer's.[21] One group examined slices of brain from patients having had multiple mild traumatic brain injuries and found changes in the cells'cytoskeletons, which they suggested might be due to damage to cerebralblood vessels.[22]
Increased exposure to concussions and subconcussive blows is regarded as the most important risk factor. In boxing, this exposure can depend on the total number of fights, number of knockout losses, duration of career, fight frequency, age of retirement, and boxing style.[23]
Diagnosis of CTE cannot be made in living individuals; a clear diagnosis is only possible during an autopsy.[24] Though there are signs and symptoms some researchers associate with CTE, there is no definitive test to prove the existence in a living person. Signs are also very similar to those of other neurological conditions, such as Alzheimer's.[25]
The lack of distinctbiomarkers is the reason CTE cannot typically be diagnosed while a person is alive. Concussions are non-structural injuries and do not result in brain bleeding, which is why most concussions cannot be seen on routine neuroimaging tests such as CT or MRI.[26] Acute concussion symptoms (those that occur shortly after an injury) should not be confused with CTE. Differentiating between prolongedpost-concussion syndrome (PCS, where symptoms begin shortly after a concussion and last for weeks, months, and sometimes even years) and CTE symptoms can be difficult. Research studies are examining whether neuroimaging can detect subtle changes inaxonal integrity and structural lesions that can occur in CTE.[6] By the early 2010s, more progress inin-vivo diagnostic techniques for CTE had been made, usingDTI,fMRI,MRI, andMRS imaging; however, more research needs to be done before any such techniques can be validated.[16]
PET tracers that bind specifically totau protein are desired to aid the diagnosis of CTE in living individuals. One candidate is the tracer [18F]FDDNP, which is retained in the brain in individuals with several dementing disorders such asAlzheimer's disease,Down syndrome,progressive supranuclear palsy,corticobasal degeneration,familial frontotemporal dementia, andCreutzfeldt–Jakob disease.[27] In a small study of 5 retired NFL players with cognitive and mood symptoms, the PET scans revealed accumulation of the tracer in their brains.[28] However, [18F]FDDNP binds tobeta-amyloid and other proteins as well. Moreover, the sites in the brain where the tracer was retained were not consistent with the known neuropathology of CTE.[29] A more promising candidate is the tracer [18F]-T807, which binds only to tau. It is being tested in several clinical trials.[29][needs update]
A putative biomarker for CTE is the presence in serum ofautoantibodies against the brain. The autoantibodies were detected in football players who experienced a large number of head hits but no concussions, suggesting that even sub-concussive episodes may be damaging to the brain. The autoantibodies may enter the brain using a disruptedblood-brain barrier, and attack neuronal cells which are normally protected from an immune onslaught.[30] Given the large numbers of neurons present in the brain (86 billion), and considering the poor penetration of antibodies across a normal blood-brain barrier, there is an extended period between the initial events (head hits) and the development of any signs or symptoms. Nevertheless, autoimmune changes in blood of players may constitute the earliest measurable event predicting CTE.[31]
Although the diagnosis of CTE cannot be determined by imaging, the effects of head trauma may be seen with the use of structural imaging.[32] Imaging techniques include the use ofmagnetic resonance imaging,nuclear magnetic resonance spectroscopy,CT scan,single-photon emission computed tomography,Diffusion MRI, andPositron emission tomography (PET).[32] One specific use of imaging is the use of a PET scan is to evaluate fortau deposition, which has been conducted on retiredNFL players.[33]
The use of helmets and mouth guards has been put forward as a possible preventative measure; though neither has significant research to support its use,[34] both have been shown to reduce direct head trauma.[35] Although there is no significant research to support the use of helmets to reduce the risk of concussions, there is evidence to support that helmet use reduces impact forces. The sports in which a helmet was effective in preventing TBI and concussions were skiing and snowboarding.[36] Mouth guards have been shown to decrease dental injuries, but again have not shown significant evidence to reduce concussions.[32] Because repeated impacts are thought to increase the likelihood of CTE development, a growing area of practice is improved recognition and treatment for concussions and other head trauma; removal from sport participation during recovery from these traumatic injuries is essential.[32] Proper return-to-play protocol after possible brain injuries is also important in decreasing the significance of future impacts.[32]
Efforts are being made to change the rules of contact sports to reduce the frequency and severity of blows to the head.[32] Examples of these rule changes are the evolution of tackling technique rules in American football, such as the banning of helmet-first tackles, and the addition of rules to protect defenseless players. Likewise, another growing area of debate is better implementation of rules already in place to protect athletes.[32]
Because of the concern that boxing may cause CTE, there is a movement among medical professionals to ban the sport.[9] Medical professionals have called for such a ban as early as the 1950s.[8]
No cure exists for CTE, and it cannot be diagnosed until a post-mortemautopsy is performed.[37] Treatment is supportive as with other forms ofdementia.[38] Those with CTE-related symptoms may receive medication and non-medication-related treatments.[39] Currently, there is no way to stop or slow the development of CTE. However, medications like Aricept (donepezil) and Namenda (memantine) can mitigate memory loss and confusion, and Aricept can improve memory, motivation, and attention by increasingacetylcholine levels in the brain. Memantine is a cognitive enhancer that can help with memory loss and confusion. These medications are also treatments for Alzheimer's disease and dementia.[40] There are also antidepressants likeselective serotonin reuptake inhibitors (SSRIs), which can potentially help manage some of the behavioral and emotional symptoms associated with chronic traumatic encephalopathy (CTE) and may have a small improvement in memory function, mood, and alertness. SSRIs are often the first choice of treatment for CTE due to their effectiveness.[41]
Rates of disease are about 30% among those with a history of multiple head injuries.[1] Population rates, however, are unclear.[2] Tracking the epidemiology of CTE is difficult due to the inability to diagnose this syndrome during life.[42]
Professional level athletes are the largest group with CTE, due to frequent concussions and sub-concussive impacts from play incontact sport.[43] These contact-sports includeAmerican football,Australian rules football,[44]ice hockey,Rugby football (Rugby union andRugby league),[45]boxing,kickboxing,mixed martial arts,association football,[46][45] andwrestling.[47] In association football, only prolificheaders are known to have developed CTE.[46]
Cases of CTE were also recorded in baseball.[48]
According to a 2017 study on brains of deceased gridiron football players, 99% of tested brains ofNFL players, 88% ofCFL players, 64% of semi-professional players, 91% ofcollege football players, and 21% ofhigh school football players had various stages of CTE.[49]
As reported in a study published by Roberts, about 11% of the retired boxers he examined had a mild case of CTE, and about 6% of the boxers had major neurological problems. Through these clinical examinations, Roberts was able to establish associations between exposure to violence and the effects of CTE. He stated that among the boxers who are over the age of 50 and fought in over 150 fights, about 50% of them had CTE. This number was compared to the 7% of the boxers who had CTE and had less than 50 fights.[50]
Other individuals diagnosed with CTE were those involved in military service, had a previous history of chronicseizures, were domestically abused, or were involved in activities resulting in repetitive head collisions.[51][32][52]
CTE was originally studied in boxers in the 1920s as "punch-drunk syndrome." The punch-drunk syndrome was first described in 1928 by a forensic pathologist,Harrison Stanford Martland, who was the chief medical examiner ofEssex County inNewark, New Jersey, in aJournal of the American Medical Association article, in which he noted the tremors, slowed movement, confusion and speech problems typical of the condition.[53] The term "punch-drunk" was replaced with "dementia pugilistica" in 1937 by J.A. Millsbaugh, as he felt the term was condescending to former boxers.[54] The initial diagnosis ofdementia pugilistica was derived from theLatin word for boxer,pugil (akin topugnus 'fist',pugnāre 'to fight').[55][56]
Other terms for the condition have included chronic boxer's encephalopathy, traumatic boxer's encephalopathy, boxer's dementia, pugilistic dementia, chronic traumatic brain injury associated with boxing (CTBI-B), and punch-drunk syndrome.[3]
NeurologistMacdonald Critchley wrote a 1949 paper titled "Punch-drunk syndromes: the chronic traumatic encephalopathy of boxers".[57] CTE was first recognized as affecting individuals who took considerable blows to the head, but was believed to be confined to boxers and not other athletes. As evidence pertaining to the clinical and neuropathological consequences of repeated mild head trauma grew, it became clear that this pattern of neurodegeneration was not restricted to boxers, and the term chronic traumatic encephalopathy became most widely used.[58][59]
In 2002,Bennet Omalu[60] performed an autopsy on American football playerMike Webster. Omalu concluded that Webster was the first person to be officially diagnosed with CTE. Omalu expected the autopsy to reveal a brain affected byAlzheimer's.[61] Instead, after fixing and dissecting the brain, Omalu observed abnormal proteins tangles that distinguish CTE from Alzheimer's disease.[citation needed]
A famous case of CTE is that of former NFL playerAaron Hernandez.[62] Two years into a jail sentence for murder, Hernandez was found dead from hanging himself in his cell. An autopsy found stage 3 CTE, a severity rarely seen at his age of 27 at death.[63]
In October 2022, the United StatesNational Institutes of Health formally acknowledged there was a causal link between repeated blows to the head and CTE.[64]
In 2005, forensic pathologistBennet Omalu, along with colleagues in the Department of Pathology at the University of Pittsburgh, published a paper, "Chronic Traumatic Encephalopathy in a National Football League Player", in the journalNeurosurgery, based on analysis of the brain of deceased former NFL centerMike Webster. This was then followed by a paper on a second case in 2006 describing similar pathology, based on findings in the brain of former NFL playerTerry Long.[65]
In 2008, the Center for the Study of Traumatic Encephalopathy at theBU School of Medicine (now theBU CTE Center) started the VA-BU-CLF Brain Bank at the Bedford Veterans Administration Hospital to analyze the effects of CTE and other neurodegenerative diseases on the brain and spinal cord of athletes, military veterans, and civilians.[15][66] To date, the VA-BU-CLF Brain Bank is the largest CTE tissue repository in the world, with over 1000 brain donors.[16][67]
On 21 December 2009, theNational Football League Players Association announced that it would collaborate with theBU CTE Center to support the center's study of repetitive brain trauma in athletes.[68] Additionally, in 2010 theNational Football League gave the BU CTE Center a $1 million gift with no strings attached.[69][70] In 2008, twelve living athletes (active and retired), including hockey playersPat LaFontaine andNoah Welch as well as former NFL starTed Johnson, committed to donate their brains to VA-BU-CLF Brain Bank after their deaths.[71] In 2009, NFL Pro BowlersMatt Birk,Lofa Tatupu, andSean Morey pledged to donate their brains to the VA-BU-CLF Brain Bank.[72]
In 2010, 20 more NFL players and former players pledged to join the VA-BU-CLF Brain Donation Registry, including Chicago Bears linebackerHunter Hillenmeyer, Hall of FamerMike Haynes, Pro BowlersZach Thomas,Kyle Turley, andConrad Dobler, Super Bowl ChampionDon Hasselbeck and former pro playersLew Carpenter, andTodd Hendricks. In 2010, professional wrestlersMick Foley,Booker T andMatt Morgan also agreed to donate their brains upon their deaths. Also in 2010, MLS playerTaylor Twellman, who had to retire from the New England Revolution because of post-concussion symptoms, agreed to donate his brain upon his death. As of 2010, the VA-BU-CLF Brain Donation Registry consists of over 250 current and former athletes.[73]
In 2011, formerNorth Queensland Cowboys playerShaun Valentine became the first AustralianNational Rugby League player to agree to donate his brain upon his death, in response to recent concerns about the effects of concussions on Rugby League players, who do not use helmets. Also in 2011, boxerMicky Ward, whose career inspired the filmThe Fighter, agreed to donate his brain upon his death. In 2018, NASCAR driverDale Earnhardt Jr., who retired in 2017 citing multiple concussions, became the first auto racing competitor to agree to donate his brain upon his death.[74]
In related research, the Center for the Study of Retired Athletes, which is part of the Department of Exercise and Sport Science at theUniversity of North Carolina at Chapel Hill, is conducting research funded by National Football League Charities to "study former football players, a population with a high prevalence of exposure to prior Mild Traumatic Brain Injury (MTBI) and sub-concussive impacts, in order to investigate the association between increased football exposure and recurrent MTBI and neurodegenerative disorders such as cognitive impairment and Alzheimer's disease (AD)".[75]
In February 2011, former NFL playerDave Duerson committed suicide via a gunshot to his chest, thus leaving his brain intact.[76] Duerson left text messages to loved ones asking that his brain be donated to research for CTE.[77] The family got in touch with representatives of theBoston University center studying the condition, said Robert Stern, the co-director of the research group. Stern said Duerson's gift was the first time of which he was aware that such a request had been made by someone who had committed suicide that was potentially linked to CTE.[78] Stern and his colleagues found high levels of the protein tau in Duerson's brain. These elevated levels, which were abnormally clumped and pooled along the brain sulci,[15] are indicative of CTE.[79]
In July 2010, NHL enforcerBob Probert died of heart failure. Before his death, he asked his wife to donate his brain to CTE research because it was noticed that Probert experienced a mental decline in his 40s. In March 2011, researchers at Boston University concluded that Probert had CTE upon analysis of the brain tissue he donated. He was the second NHL player from the program at the BU CTE Center to be diagnosed with CTE postmortem.[80]
The BU CTE Center has also found indications of links betweenamyotrophic lateral sclerosis (ALS) and CTE in athletes who have participated in contact sports. Tissue for the study was donated by twelve athletes and their families to the VA-BU-CLF Brain Bank at the Bedford, MassachusettsVA Medical Center.[81]
In 2013,President Barack Obama announced the creation of theChronic Effects of Neurotrauma Consortium or CENC, a federally funded research project devised to address the long-term effects of mildtraumatic brain injury inmilitary service personnel (SMs) andveterans.[82][83][84] The CENC is a multi-center collaboration linking premiere basic science, translational, and clinical neuroscience researchers from the DoD, VA, academic universities, and private research institutes to effectively address the scientific, diagnostic, and therapeutic ramifications of mild TBI and its long-term effects.[85][86][87][88][89]
Nearly 20% of the more than 2.5 million U.S.service members (SMs) deployed since 2003 toOperation Enduring Freedom (OEF) andOperation Iraqi Freedom (OIF) have sustained at least onetraumatic brain injury (TBI), predominantlymild TBI (mTBI),[90][91] and almost 8% of all OEF/OIF Veterans demonstrate persistent post-TBI symptoms more than six months post-injury.[92][93] Unlike those head injuries incurred in most sporting events, recent military head injuries are most often the result of blast wave exposure.[94]
After a competitive application process, a consortium led byVirginia Commonwealth University was awarded funding to study brain injuries in military veterans.[85][86][87][unreliable source?][88][95][96] The project principal investigator for the CENC is David Cifu, chairman and Herman J. Flax professor[97] of the Department ofPhysical Medicine and Rehabilitation (PM&R) atVirginia Commonwealth University (VCU) inRichmond, Virginia, with co-principal investigatorsRamon Diaz-Arrastia, Professor of Neurology,Uniformed Services University of the Health Sciences,[88] and Rick L. Williams, statistician atRTI International.[citation needed]
In 2017,Aaron Hernandez, a former professional football player and convicted murderer, committed suicide at the age of 27 while in prison. His family donated his brain to theBU CTE Center.Ann McKee, the head of Center, concluded that "Hernandez had Stage 3 CTE, which researchers had never seen in a brain younger than 46 years old."[98]
In 2022, formerNRL player and coach Paul Green died by suicide at the age of 49. Green's brain was donated to theAustralian Sports Brain Bank, with his family posting on the website "In memory of our beloved Paul, we ask that you support the pioneering work of the Australian Sports Brain Bank" to raise money for further understanding of CTE.[99] A post-mortem examination revealed that Green was suffering from one of the most "severe forms" of CTE. Professor Michael Buckland said Green had "an organic brain disease which robbed him of his decision-making and impulse control." He added Green would likely have been "symptomatic for some time."[100]
Research into the genetic component of CTE is evolving and well summarized in a recent review.[101] The minor allele ofTMEM106B is associated with a protective phenotype.[101]
In 2023,Australian rules football playerHeather Anderson became the first female athlete diagnosed with CTE after her death by suicide on 13 November 2022, at the age of 28. Her brain, which was donated to theAustralian Sports Brain Bank, was found to contain multiple CTE lesions, and abnormalities were found "nearly everywhere" in the cortex.[102] Also in 2023, a study was published on 28 August inJAMA Neurology regarding brain autopsies of athletes, one of whom was the first American female athlete diagnosed with CTE; her name is unknown, but she died at age 28 and was a collegiate soccer player.[103]
In March 2024, formerrugby union playerBilly Guyton became the first New Zealand-based athlete diagnosed with CTE following his forced retirement in 2018, due to the complications of multiple concussions, and his death by suspected suicide in 2023.[104][105] His brain had been donated by his family to the Neurological Foundation Human Brain Bank at theUniversity of Auckland,[104] withpost-mortem analyses conducted in New Zealand and Australia eventually finding "background changes consistent with globalhypoxic ischaemic encephalopathy",[104] as well as trauma-inducedcavum septum pellucidum and age-relatedtau deposits.[105]
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