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Cholinem-bromophenyl ether

From Wikipedia, the free encyclopedia
Cholinem-bromophenyl ether
Names
Preferred IUPAC name
2-(3-Bromophenoxy)-N,N,N-trimethylethan-1-aminium
Other names
MBF
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C11H17BrNO/c1-13(2,3)7-8-14-11-6-4-5-10(12)9-11/h4-6,9H,7-8H2,1-3H3/q+1
    Key: OOVBETAQGQVMNH-UHFFFAOYSA-N
  • C[N+](C)(C)CCOc1cccc(c1)Br
Properties
C11H17BrNO
Molar mass259.167 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Cholinem-bromophenyl ether (MBF) is an extremely potentnicotinic agonist. It has powerful ganglion stimulating effects.[1][2] It also causesmuscle contractions.[3]

References

[edit]
  1. ^HEY, P (March 1952)."On relationships between structure and nicotine-like stimulant activity in choline esters and ethers".British Journal of Pharmacology and Chemotherapy.7 (1):117–29.doi:10.1111/j.1476-5381.1952.tb00697.x.PMC 1509269.PMID 14904910.
  2. ^AMBACHE, N; ROBERTSON, PA (June 1953)."The nicotine-like actions of the 3-bromo-and 3:5-dibromo-phenyl ethers of choline (MBF and DBF)".British Journal of Pharmacology and Chemotherapy.8 (2):147–55.doi:10.1111/j.1476-5381.1953.tb00769.x.PMC 1509335.PMID 13066713.
  3. ^WILLEY, GL (December 1955)."Stimulant activities of quaternary ammonium compounds on mammalian skeletal muscle".British Journal of Pharmacology and Chemotherapy.10 (4):466–73.doi:10.1111/j.1476-5381.1955.tb00107.x.PMC 1509544.PMID 13276606.
nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(andPAMsTooltip positive allosteric modulators)
Antagonists
(andNAMsTooltip negative allosteric modulators)
Precursors
(andprodrugs)


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