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Chlorphenesin carbamate

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(Redirected fromChlorphenesin)
Muscle relaxant drug
Pharmaceutical compound
Chlorphenesin carbamate
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Pharmacokinetic data
Excretionurine
Identifiers
  • (3-(4-chlorophenoxy)-2-hydroxypropyl)carbamate
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.002.902Edit this at Wikidata
Chemical and physical data
FormulaC10H12ClNO4
Molar mass245.66 g·mol−1
3D model (JSmol)
Melting point86 to 92 °C (187 to 198 °F)
  • c1cc(ccc1OCC(COC(=O)N)O)Cl
  • InChI=1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14)
  • Key:SKPLBLUECSEIFO-UHFFFAOYSA-N

Chlorphenesin carbamate (Maolate,Musil) is a centrally actingmuscle relaxant used to treat muscle pain andspasms.[1][2] Chlorphenesin carbamate is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such asbenzodiazepines.

Other central effects include sedation,anxiolysis, and dizziness.

Chlorphenesin

[edit]

A related chemical, chlorphenesin (C9H11ClO3)without thecarbamate group, is used as a preservative in products such as cosmetics. It hasantifungal and someantibacterial properties, and is classified as an antifungal for topical use by the WHO.[3]

The major adverse effect from this preservative on skin isallergic contact sensitivity.[4][5] Systemic intoxication fromtransdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.[6]

See also

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References

[edit]
  1. ^Okuyama S, Aihara H (February 1987). "Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats".Research Communications in Chemical Pathology and Pharmacology.55 (2):147–60.PMID 3823606.
  2. ^Kurachi M, Aihara H (September 1984)."Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats".Japanese Journal of Pharmacology.36 (1):7–13.doi:10.1254/jjp.36.7.PMID 6503049.
  3. ^ATC code D01AE07
  4. ^Brown R (May 1981). "Chlorphenesin sensitivity".Contact Dermatitis.7 (3): 162.doi:10.1111/j.1600-0536.1981.tb04601.x.PMID 6456118.S2CID 37580364.
  5. ^Burns DA (April 1986). "Allergic contact sensitivity to chlorphenesin".Contact Dermatitis.14 (4): 246.doi:10.1111/j.1600-0536.1986.tb01234.x.PMID 2941223.S2CID 43810471.
  6. ^"FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants".Food and Drug Administration.
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