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| Names | |
|---|---|
| Preferred IUPAC name (2R,3R)-2,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid | |
| Other names Cichoric acid; (2R,3R)-O-Dicaffeoyltartaric acid | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider |
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| ECHA InfoCard | 100.109.212 |
| KEGG |
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| UNII | |
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| Properties | |
| C22H18O12 | |
| Molar mass | 474.371 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Chicoric acid (also known ascichoric acid) is ahydroxycinnamic acid, an organic compound of thephenylpropanoid class and occurs in a variety of plant species. It is a derivative of bothcaffeic acid andtartaric acid.[1]
As a suitable marker for the distinction ofEchinacea species, it is often assayed usingRP-HPLC andThin layer chromatography (TLC) methods.[2]
Chicoric acid has first been isolated fromCichorium intybus (chicory) but also occurs in significant amounts inEchinacea, in particularE. purpurea,dandelion leaves,basil,lemon balm, andaquatic plants, includingalgae andseagrasses.[3][4][5][6]
Chicoric acid has been shown to stimulatephagocytosis in bothin vitro andin vivo studies, to inhibit the function ofhyaluronidase (an enzyme that breaks downhyaluronic acid in the human body), to protectcollagen from damage due tofree radicals, and to inhibit the function ofHIV-1integrase.[7][8]
