Achannel modulator, orion channel modulator, is a type of drug which modulatesion channels. They includechannel blockers andchannel openers.[1]
Ion channels are typically categorised by gating mechanism and by the ion they conduct. Note that an ion channel may overlap between different categories. Some channels conduct multiple ion currents and some are gated by multiple mechanisms.
Examples of targets for modulators include:
Ion channels gated by other mechanisms (e.g. light gated andmechanosensitive ion channels). These types of channels can also be pharmacologically modulated. For lists of the substances that pharmacologically modulate them, see their respective articles.
Ion channels can also be modulated indirectly. For example withG protein coupled receptors (GPCRs), forG protein coupled inward rectifier potassium channels (GIRKs) and M channels. Ion channels can also be modulated byreuptake inhibitors andreleasing agents.
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