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| Clinical data | |
|---|---|
| Trade names | Intracef, Velocef |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a601206 |
| Routes of administration | Oral,IM,IV |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | Well absorbed |
| Protein binding | <10% |
| Metabolism | Nil |
| Eliminationhalf-life | 0.9 hours |
| Excretion | Renal, unchanged |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| IUPHAR/BPS | |
| DrugBank |
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| ChemSpider |
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| UNII | |
| KEGG |
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| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.049.199 |
| Chemical and physical data | |
| Formula | C16H19N3O4S |
| Molar mass | 349.41 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 140 to 142 °C (284 to 288 °F) (dec.) |
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| (verify) | |
Cefradine (INN) orcephradine (BAN) is a first generationcephalosporinantibiotic.[1]
Cefradine is distributed in the form of capsules containing 250 mg or 500 mg, as a syrup containing 250 mg/5 ml, or in vials for injection containing 500 mg or 1 g.[citation needed]
It is not approved by the FDA for use in the United States.[citation needed]
Birch reduction of D-α-phenylglycine led to diene (2). This was N-protected usingtert-butoxycarbonylazide and activated for amide formation via the mixed anhydride method using isobutylchloroformate to give3. Mixed anhydride3 reacted readily with 7-aminodesacetoxycephalosporanic acid to give, after deblocking, cephradine (5).
The antibiotic is produced under many brand names across the world.[5]
Bangladesh: Ancef, Ancef forte, Aphrin, Avlosef, Cefadin, Cephadin, Cephran, Cephran-DS, Cusef, Cusef DS, Dicef, Dicef forte, Dolocef, Efrad, Elocef, Extracef, Extracef-DS, Intracef, Kefdrin, Lebac, Lebac Forte, Medicef, Mega-Cef, Megacin, Polycef, Procef, Procef, Procef forte, Rocef, Rocef Forte DS, Sefin, Sefin DS, Sefnin, Sefrad, Sefrad DS, Sefril, Sefril-DS, Sefro, Sefro-HS, Sephar, Sephar-DS, Septa, Sinaceph, SK-Cef, Sk-Cef DS, Supracef and Supracef-F, Torped, Ultrasef, Vecef, Vecef-DS, Velogen, Sinaceph, Velox
China: Cefradine, Cephradine, Kebili, Saifuding, Shen You, Taididing, Velosef, Xianyi, and Xindadelei
Colombia: Cefagram, Cefrakov, Cefranil, Cefrex, and Kliacef
Egypt: Cefadrin, Cefadrine, Cephradine, Cephraforte, Farcosef, Fortecef, Mepadrin, Ultracef, and Velosef
France: Dexef
Hong Kong: Cefradine and ChinaQualisef-250
Indonesia: Dynacef, Velodine, and Velodrom
Lebanon: Eskacef, Julphacef, and Velosef
Lithuania: Tafril
Myanmar: Sinaceph
Oman: Ceframed, Eskasef, Omadine, and Velocef
Pakistan: Abidine, Ada-Cef, Ag-cef, Aksosef, Amspor, Anasef, Antimic, Atcosef, Bactocef, Biocef, Biodine, Velora, Velosef
Peru: Abiocef, Cefradinal, Cefradur, Cefrid, Terbodina II, Velocef, Velomicin
Philippines: Altozef, Racep, Senadex, Solphride, Yudinef, Zefadin, Zefradil, and Zolicef
Poland: Tafril
Portugal: Cefalmin, Cefradur
South Africa: Cefril A
South Korea: Cefradine and Tricef
Taiwan: Cefadin, Cefamid, Cefin, Cekodin, Cephradine, Ceponin, Lacef, Licef-A, Lisacef, Lofadine, Recef, S-60, Sefree, Sephros, Topcef, Tydine, Unifradine, and U-Save
UK: Cefradune (Kent)
Vietnam: Eurosefro and Incef