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Centrin 1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

CETN1
Identifiers
AliasesCETN1, CEN1, CETN, centrin 1
External IDsOMIM:603187;MGI:1347086;HomoloGene:105668;GeneCards:CETN1;OMA:CETN1 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for CETN1
Genomic location for CETN1
Band18p11.32Start580,380bp[1]
End582,114bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for CETN1
Genomic location for CETN1
Band18|18 A1Start9,615,524bp[2]
End9,619,478bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • sperm

  • testicle

  • human musculoskeletal system

  • muscular system

  • muscle

  • muscle

  • skeletal muscle

  • lower limb muscles
Top expressed in
  • spermatid

  • spermatocyte

  • seminiferous tubule

  • lumbar subsegment of spinal cord

  • motor neuron

  • tibiofemoral joint

  • submandibular gland

  • spinal ganglia

  • carotid body

  • trachea
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1068

26369

Ensembl

ENSG00000177143

ENSMUSG00000050996

UniProt

Q12798

P41209

RefSeq (mRNA)

NM_004066

NM_007593

RefSeq (protein)

NP_004057

NP_031619

Location (UCSC)Chr 18: 0.58 – 0.58 MbChr 18: 9.62 – 9.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrin-1 is aprotein that in humans is encoded by theCETN1gene.[5][6] It belongs to thecentrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000177143 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000050996 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Errabolu R, Sanders MA, Salisbury JL (Jun 1994)."Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles".J Cell Sci. 107. ( Pt 1):9–16.doi:10.1242/jcs.107.1.9.PMID 8175926.
  6. ^ab"Entrez Gene: CETN1 centrin, EF-hand protein, 1".

External links

[edit]

Further reading

[edit]
PDB gallery
  • 1m39: Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form
    1m39: Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form
  • 2a4j: Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein
    2a4j: Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein


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