Experimental antidepressant
Pharmaceutical compound
Centpropazine (CPZ,CTZ) is anexperimentalantidepressant which was under development for the treatmentmajor depressive disorder inIndia but was never marketed.[1][2][3] It is described as havingimipramine-like clinical effects, reversingreserpine-induced effects in animals, and potentiatingamphetamine-induced effects in animals.[3] Themechanism of action of centpropazine is unknown.[4] The drug reachedphase 3clinical trials prior to the discontinuation of its development.[1] It was first described in thescientific literature by 1980.[3][5]
- ^abc"Centpropazine".AdisInsight. Springer Nature Switzerland AG. 10 December 2013. Retrieved27 September 2024.
- ^Avasthi A, Grover S, Aggarwal M (January 2010)."Research on antidepressants in India".Indian Journal of Psychiatry.52 (Suppl 1):S341 –S354.doi:10.4103/0019-5545.69263.PMC 3146188.PMID 21836704.
- ^abcKaiser C, Bondinell WE (1981). "Chapter 1. Antidepressants".Annual Reports in Medicinal Chemistry. Vol. 16. Elsevier. p. 1–10.doi:10.1016/s0065-7743(08)61268-3.ISBN 978-0-12-040516-9.ISSN 0065-7743.
- ^shrafuzzaman M, Ji SH, Ahn H, Chung HW, Choi D, Park JJ, Go M, Pyo JI, Shafioul AS, Lee DH, Chi SG (29 March 2023)."Identification of 1-phenoxy-3-(piperazin-1-yl)propan-2-ol derivatives as novel triple reuptake inhibitors".Bulletin of the Korean Chemical Society.44 (7). Wiley:596–599.doi:10.1002/bkcs.12693.ISSN 1229-5949.
- ^Singh H, Chawla AS, Kapoor VK (1985). "Medicinal chemistry research in India".Progress in Medicinal Chemistry.22:243–266.doi:10.1016/s0079-6468(08)70232-7.ISBN 978-0-444-80668-0.PMID 2873624.
