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Cendifensine

From Wikipedia, the free encyclopedia

Pharmaceutical compound
Cendifensine
Clinical data
Drug classMonoamine reuptake inhibitor
Identifiers
  • (3,4-dichlorophenyl)-[(3S)-3-propylpyrrolidin-3-yl]methanone
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC14H17Cl2NO
Molar mass286.20 g·mol−1
3D model (JSmol)
  • CCC[C@@]1(CCNC1)C(=O)C2=CC(=C(C=C2)Cl)Cl
  • InChI=1S/C14H17Cl2NO/c1-2-5-14(6-7-17-9-14)13(18)10-3-4-11(15)12(16)8-10/h3-4,8,17H,2,5-7,9H2,1H3/t14-/m0/s1
  • Key:HVLPRTLORBIKNG-AWEZNQCLSA-N

Cendifensine (INNTooltip International Nonproprietary Name) is amonoamine reuptake inhibitor (MRI)[1] related to theamphetamines andcathinones which has not been marketed at this time.[2][3][4] It was first described by 2013[4] and itsINNTooltip International Nonproprietary Name was proposed in 2024.[2] The drug has beenpatented by Noema Pharma, which is developing aserotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) known as NOE-115 for the treatment ofvasomotor symptoms associated with menopause as well as forbinge-eating disorder anddepressive disorders.[5][6][7]

See also

[edit]

References

[edit]
  1. ^WO 2023/161533A1, Garibaldi G, "Triple uptake inhibitor for the treatment of atypical depression", published 31 August 2023, assigned to Noema Pharma AG 
  2. ^ab"Proposed INN: List 132 International Nonproprietary Names for Pharmaceutical Substances (INN)"(PDF).WHO Drug Information.38 (4). 2024.cendifensinum cendifensine (3,4-dichlorophenyl)[(3S)-3-propylpyrrolidin-3-yl]methanone monoamine reuptake inhibitor [...] C14H17Cl2NO 1034048-49-1
  3. ^"(3,4-Dichlorophenyl)[(3S)-3-propyl-3-pyrrolidinyl]methanone".Global Substance Registration System (GSRS). National Center for Advancing Translational Sciences (NCATS), U.S. National Institutes of Health. Retrieved24 February 2025.
  4. ^abCA 2860810A1, Adam JM, Dvorak CA, Fishlock D, Humphreys ER, Iding H, Pfleger C, Rege PD, Shi X, Vitale J, Wang S, Zajac M, "(3,4-dichloro-phenyl)-((s)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes", published 23 April 2013, assigned to F Hoffmann La Roche AG 
  5. ^"NOE 115".AdisInsight. 21 May 2024. Retrieved24 February 2025.
  6. ^"Delving into the Latest Updates on Noema Pharma AG with Synapse".Synapse. 23 January 2025. Retrieved24 February 2025.
  7. ^"Noema Pharma".Noema Pharma. 18 June 2021. Retrieved24 February 2025.
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
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