CatSper2, is aprotein which in humans is encoded by theCATSPER2gene.[5][6] CatSper2 is a member of thecation channels of sperm family of protein. The four proteins in this family together form aCa2+-permeantion channel specific essential for the correct function of sperm cells.[7]
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific tospermatozoa and localize to theflagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be apseudogene.[8]
^Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels".Pharmacol. Rev.57 (4):451–4.doi:10.1124/pr.57.4.7.PMID16382101.S2CID35096827.
Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels".Pharmacol. Rev.57 (4):451–4.doi:10.1124/pr.57.4.7.PMID16382101.S2CID35096827.
