Enzyme found in humans
CASP6 Available structures PDB Ortholog search:PDBe RCSB List of PDB id codes 2WDP ,3K7E ,3NKF ,3NR2 ,3OD5 ,3P45 ,3P4U ,3QNW ,3S70 ,3S8E ,3V6L ,3V6M ,4EJF ,4FXO ,4HVA ,4IYR ,4N5D ,4N6G ,4N7J ,4N7M ,4NBK ,4NBL ,4NBN
Identifiers Aliases CASP6 External IDs OMIM :601532 ;MGI :1312921 ;HomoloGene :37455 ;GeneCards :CASP6 ;OMA :CASP6 - orthologs Wikidata
Caspase-6 is anenzyme that in humans is encoded by theCASP6 gene .[ 5] [ 6] CASP6 orthologs [ 7] mammals for which complete genome data are available. Unique orthologs are also present inbirds ,lizards ,lissamphibians , andteleosts . Caspase-6 has known functions inapoptosis ,[ 8] immune response [ 9] [ 10] neurodegeneration inHuntington's andAlzheimer's disease .[ 11]
This gene encodes a protein that is a member of thecysteine -aspartic acid protease (caspase ) family. Sequential activation of caspases plays a central role in the execution-phase of cellapoptosis .[ 8] proenzymes that undergoproteolytic processing at conserved aspartic residues to produce two subunits, large and small, thatdimerize to form the active enzyme. This protein is processed bycaspases 7 ,8 and10 , and is thought to function as a downstream enzyme in the caspase activation cascade. Caspase 6 can also undergo self-processing without other members of the caspase family.[ 12] Alternative splicing of this gene results in two transcript variants that encode different isoforms.[ 13]
Caspase-6 plays a role in the early immune response via de-repression. It reduces the expression of the immunosuppressant cytokineinterleukin-10 [ 9] IRAK-M .[ 10]
With respect toneurodegeneration , caspase-6 cleavesHTT inHuntington's andAPP inAlzheimer's disease . Resulting in both cases inprotein aggregation of the fragments.[ 11]
Caspase 6 has been shown tointeract withCaspase 8 .[ 14] [ 15] [ 16]
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Activity Regulation Classification Kinetics Types
