American immunologist and oncologist
Carl H. June (born 1953) is an American immunologist and oncologist. He is currently theRichard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine at thePerelman School of Medicine of theUniversity of Pennsylvania .[ 1] T cell therapies for the treatment of several forms of cancers. In 2020 he was elected to theAmerican Philosophical Society .[ 2]
Education and career [ edit ] June graduated from theUS Naval Academy in 1975 and earned his medical degree in from theBaylor College of Medicine in 1979.[ 3] World Health Organization in Geneva, Switzerland, studying immunology and malaria with Dr. Paul Henri-Lambert, and completed clinical training in internal medicine and medical oncology from 1979 to 1983 at theNational Naval Medical Center in Bethesda, Maryland. June conducted postdoctoral research in transplantation biology withE. Donnall Thomas and John Hansen at theFred Hutchinson Cancer Center in Seattle from 1983 to 1986. After completing his training, he returned to Bethesda, where he founded the Immune Cell Biology Program at theNaval Medical Research Center and was head of the department of immunology from 1990 to 1995. He was also a professor of medicine and of cell and molecular biology at theUniformed Services University for the Health Sciences. In 1999 June joined the University of Pennsylvania as a professor of molecular and cellular engineering at the University of Pennsylvania's school of medicine and investigator at the Abramson Family Cancer Research Institute, where he remains today. He is board-certified in internal medicine and oncology.[ 4]
June has been a pioneer in the field of immunotherapy, most widely known for the development of T-cell therapy for cancer.[ 5] CD28 molecule as the major control switch for T cells.[ 6] CAR-Ts in humans, discovering the cells could engraft and persist in patients with HIV/AIDS for years.[ 5] tisagenlecleucel , the first FDA-approved cell therapy.
1978 –Alpha Omega Alpha Medical Society. 1978 – Michael E. DeBakey Scholar award for the Outstanding Medical Student, Baylor College of Medicine 1991 – Fellow,American College of Physicians . 1996 – Legion of Merit, US Navy 1996 – Dexter Conrad Award, Office of Naval Research, Navy’s highest award for Scientific Achievement 1997 – Frank Brown Berry Prize in Federal Medicine 2001 – Burroughs Wellcome Fund Award: visiting professor in the basic medical sciences 2002 – Lifetime Achievement Award,Leukemia and Lymphoma Society 2002 – William Osler Award, University of Pennsylvania School of Medicine 2005–09 – Bristol-Myers Squibb Freedom to Discover Award 2005 – Federal Laboratory Award for Excellence in Technology Transfer. 2012 –William B. Coley Award for Distinguished Research in Basic and Tumor Immunology 2012 – Ernest Beutler Lecture and Prize, American Society of Hematology 2012 – Elected toInstitute of Medicine 2013 –The Philadelphia Award 2013 – Richard V Smalley Award, Society for Immunotherapy of Cancer 2014 – Elected toAmerican Academy of Arts and Sciences . 2014 – Steinman Award for Human Immunology Research, American Association of Immunologists 2014 – Aubrey Evans Award / Ronald McDonald House 2014 – Karl Landsteiner Memorial Award, AABB. 2014 – Taubman Prize for Excellence in Translational Medical Science 2014 –Hamdan Award for Medical Research Excellence 2015 –Paul Ehrlich and Ludwig Darmstaedter Prize . 2015 – Watanabe Prize for Translational Research, Indiana University and Eli Lilly 2015 – Lifetime Achievement Award Lecture, Miami Winter Symposium 2015 – Debrecen Award for Molecular Medicine, University of Debrecen 2015 – AACR-CRI Lloyd J. Old Award in Cancer Immunology. 2015 – Award for Distinguished Research in the Biomedical Sciences, Association of American Medical Colleges 2015 – E. Donnall Thomas Award Lecture, American Society for Blood and Marrow Transplantation 2016 –John Scott Medal 2016 – Distinguished Graduate Award, U.S. Naval Academy. 2016 – Novartis Prize in Immunology 2016 – Clinical Research Achievement Award.[ 7] 2017 – Karnofsky Prize, ASCO 2017 – Distinguished Scientist Award, Association of American Cancer Institutes 2018 –Time 100 : The Most Influential People of 2018[ 8] 2018 –Albany Medical Center Prize in Medicine and Biomedical Research.[ 9] 2018 – Passano Prize 2019 – ACTS Distinguished Investigator: Translation from Proof-of-Concept to Applicability for Widespread Clinical Practice Award 2019 – Harrington Prize, American Society for Clinical Investigation 2019 – The Edward Netter Leadership Award, Alliance for Cancer Gene Therapy[ 10] 2020 –Lorraine Cross Award [ 11] 2020 – Elected member American Philosophical Society 2020 – Genome Valley Excellence Award, BioAsia 2020 – Elected member National Academy of Sciences 2021 –Dan David Prize [ 12] 2021 – Outstanding Achievement Award, American Society of Gene & Cell Therapy 2022 – The Keio Medical Science Prize[ 13] 2022 – Maria I. New International Prize for Biomedical Research[ 14] 2023 – Phacilitate Lifetime Achievement Award[ 15] 2023 –Clarivate Citation Laureates [ 16] 2024 –Breakthrough Prize in Life Sciences [ 17] 2024 –Abarca Prize , for CAR-T cell therapy to fight blood cancer[ 18] 2024 –VinFuture Prize , alongsideZelig Eshhar , andMichel Sadelain for the development and advancement ofCAR T cell therapy.[ 19] 2025 –Balzan Prize [ 20] 2025 –Broermann Medical Innovation Award [ 21] 2025 –BBVA Foundation Frontiers of Knowledge Award in the category "Biology and Biomedizin" jointly with Michel Sadelain.[ 22] ^ "June Lab" .Penn Medicine Center for Cellular Immunotherapies .^ "The American Philosophical Society Welcomes New Members for 2020" .^ "Carl H. June – Faculty – About Us – Perelman School of Medicine – Perelman School of Medicine at the University of Pennsylvania" .www.med.upenn.edu .^ "Carl H. June, MD" . aacr.org. Archived fromthe original on 2019-10-31. Retrieved2016-12-05 .^a b "2015 Award for Distinguished Research in the Biomedical Sciences – AAMC Awards – Initiatives – AAMC" . aamc.org. Retrieved2016-12-05 .^ June, Carl H; Ledbetter, Jeffrey A; Linsley, Peter S; Thompson, Craig B (January 1990). "Role of the CD28 receptor in T-cell activation".Immunology Today .11 (6):211– 216.doi :10.1016/0167-5699(90)90085-n .hdl :2027.42/28838 PMID 2162180 . ^ "Penn Researchers Earn Clinical Research Achievement Awards – PR News" .www.uphs.upenn.edu .^ "Carl June named one of TIME Magazine's Most Influential People – Penn Today" .PennToday . 24 April 2018.^ Albany Medical Center Prize 2018 ^ "Alliance for Cancer Gene Therapy honors cancer pioneer Dr. Carl June at April 18 Gala" .^ "Dr. Carl June" .^ Dan David Prize 2021 ^ "Keio Medical Science Prize – Keio University Medical Science Fund" .^ "Carl H. June is Recipient of Inaugural Maria I. New International Prize for Biomedical Research | Mount Sinai – New York" .^ "Advanced Therapy Awards" .^ "Citation Laureates 2023_Physiology or Medicine" .Citation Laureates . Clarivate. September 19, 2023.Archived from the original on September 19, 2023. RetrievedSeptember 19, 2023 .^ "BREAKTHROUGH PRIZE ANNOUNCES 2024 LAUREATES IN LIFE SCIENCES, FUNDAMENTAL PHYSICS, AND MATHEMATICS" .BREAKTHROUGH PRIZE . September 14, 2023. RetrievedSeptember 14, 2023 .^ prnoticias, redacción (2024-10-30)."El Dr. Carl H. June recoge el galardón de la IV edición de 'Abarca Prize' .PR Noticias (in Spanish). Retrieved2024-11-06 . ^ "The VinFuture 2024 Grand Prize honours 5 scientists for transformational contributions to the advancement of deep learning" .Việt Nam News ^ Balzan Prize 2025 ^ "Dr. Carl June and Dr. Michel Sadelain to Receive Broermann Medical Innovation Award 2025" .Reuters . 2025-09-18.^ BBVA Foundation Frontiers of Knowledge Award 2025
International National Academics People
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