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Capuride

From Wikipedia, the free encyclopedia
Sedative-hypnotic drug

Pharmaceutical compound
Capuride
Clinical data
Other namesPacinox, valnoctylurea
Identifiers
  • N-carbamoyl-2-ethyl-3-methylpentanamide
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC9H18N2O2
Molar mass186.255 g·mol−1
3D model (JSmol)
  • CCC(C)C(CC)C(=O)NC(=O)N
  • InChI=InChI=1S/C9H18N2O2/c1-4-6(3)7(5-2)8(12)11-9(10)13/h6-7H,4-5H2,1-3H3,(H3,10,11,12,13)
  • Key:HLSLSXBFTXUKCY-UHFFFAOYSA-N

Capuride is a syntheticsedative-hypnotic drug of theN-acylurea class, primarily developed and studied as apreanesthetic agent to promote sleep prior to surgery.[1] It has a mechanism and duration of action considered similar to that of short-actingbarbiturates, although it is chemically distinct. Clinical studies from the 1970s demonstrated capuride's efficacy in facilitating presurgical sleep, situating it among early modern hypnotic agents, but its clinical use has been superseded by safer alternatives.[2]

References

[edit]
  1. ^Katz J, Finestone SC, Pappas MT, Fine J (May 1970). "A double-blind evaluation of capuride (Pacinox) as a presurgical aid to sleep".Current Therapeutic Research, Clinical and Experimental.12 (5):255–260.PMID 4986240.
  2. ^Weiss H (February 1971). "Capuride for sleep in rehabilitation patients: a controlled trial".Archives of Physical Medicine and Rehabilitation.52 (2):68–72.PMID 4927636.
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