Acalcium channel opener is a type ofdrug which facilitatesion transmission throughcalcium channels.
An example isBay K8644, which is ananalogue ofnifedipine that specifically and directly activatesL-typevoltage-dependent calcium channels.[1]
In contrast to Bay K8644, which is not for clinical use,ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores.[2] This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type.[3][4]
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