CT works by activating theG-proteinsGs andGq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.[9] It may also affect the ovaries in women and the testes in men.
The function of the CT receptor protein is modified through its interaction withReceptor activity-modifying proteins (RAMPs), forming the multimericamylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).[10]
Structure of human calcitonin receptor-Gs complex. The transmembrane calcitonin receptor (blue) is bound to human calcitonin (red) and the Gs complex (yellow).PDB:7TYO
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