Inhibitors of CYP2C8 can be classified by theirpotency, such as:
Strong inhibitor being one that causes at least a five-fold increase in the plasmaAUC values, or more than 80% decrease inclearance.[6]
Moderate inhibitor being one that causes at least a two-fold increase in the plasma AUC values, or 50-80% decrease in clearance.[6]
Weak inhibitor being one that causes at least a 1.25-fold but less than two-fold increase in the plasma AUC values, or 20-50% decrease in clearance.[6]
Selected inducers, inhibitors and substrates of CYP2C8
Along with CYP2C8,CYP2C9,CYP2C19,CYP2J2, and possiblyCYP2S1 are the main producers of EETs and, very likely, EEQs, EDPs, and the epoxides of linoleic acid.[12][13]
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^Shahabi P, Siest G, Meyer UA, Visvikis-Siest S (November 2014). "Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders".Pharmacology & Therapeutics.144 (2):134–61.doi:10.1016/j.pharmthera.2014.05.011.PMID24882266.
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