CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[5][6][7][8] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.
Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (January 2004). "HIV-1 infection and chemokine receptor modulation".Current HIV Research.2 (1):39–50.doi:10.2174/1570162043484997.PMID15053339.
Ignatius R, Wei Y, Beaulieu S, Gettie A, Steinman RM, Pope M, Mojsov S (July 2000). "The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells".AIDS Research and Human Retroviruses.16 (11):1055–9.doi:10.1089/08892220050075318.PMID10933620.
Unutmaz D, Xiang W, Sunshine MJ, Campbell J, Butcher E, Littman DR (September 2000). "The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse".Journal of Immunology.165 (6):3284–92.doi:10.4049/jimmunol.165.6.3284.PMID10975845.S2CID2518260.
Matloubian M, David A, Engel S, Ryan JE, Cyster JG (October 2000). "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo".Nature Immunology.1 (4):298–304.doi:10.1038/79738.PMID11017100.S2CID22773861.
Calabresi PA, Yun SH, Allie R, Whartenby KA (June 2002). "Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells".Journal of Neuroimmunology.127 (1–2):96–105.doi:10.1016/S0165-5728(02)00106-6.PMID12044980.S2CID46059196.
Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, Markham RB, Johnson L, O'Brien SJ, Vlahov D, Winkler CA (June 2003). "Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans".Genes and Immunity.4 (4):245–50.doi:10.1038/sj.gene.6363950.PMID12761559.S2CID6657058.
Koprak S, Matheravidathu S, Springer M, Gould S, Dumont FJ (May 2003). "Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin".Cellular Immunology.223 (1):1–12.doi:10.1016/S0008-8749(03)00130-8.PMID12914753.
Shimaoka T, Nakayama T, Fukumoto N, Kume N, Takahashi S, Yamaguchi J, Minami M, Hayashida K, Kita T, Ohsumi J, Yoshie O, Yonehara S (February 2004). "Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells".Journal of Leukocyte Biology.75 (2):267–74.doi:10.1189/jlb.1003465.PMID14634054.S2CID18245723.
"Chemokine Receptors: CXCR6".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2008-06-07. Retrieved2008-12-04.
