| Type I cytokine receptor, cytokine-binding domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TypeI_recpt_CBD | ||||||||
| Pfam | PF09240 | ||||||||
| Pfam clan | CL0159 | ||||||||
| InterPro | IPR015321 | ||||||||
| SCOP2 | 1n26 /SCOPe /SUPFAM | ||||||||
| Membranome | 2 | ||||||||
| |||||||||
Type Icytokine receptors aretransmembrane receptors expressed on the surface of cells that recognize and respond tocytokines with fourα-helical strands. These receptors are also known under the namehemopoietin receptors, and share a commonamino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved inligand/cytokine interaction and others that are involved insignal transduction.
The common cytokine-binding domain is related to theFibronectin type III domain.
The signal transducing chains are often shared between different receptors within this receptor family.[1]
Type I cytokine receptors includeinterleukin receptors,colony stimulating factor receptors and other cytokine receptors