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CSF2RB

From Wikipedia, the free encyclopedia
Mammalian protein found in humans
CSF2RB
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1C8P,1EGJ,1GH7,2GYS,4NKQ,5DWU,2NA9,2NA8

Identifiers
AliasesCSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
External IDsOMIM:138981;MGI:1339760;HomoloGene:339;GeneCards:CSF2RB;OMA:CSF2RB - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CSF2RB
Genomic location for CSF2RB
Band22q12.3Start36,913,628bp[1]
End36,940,439bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for CSF2RB
Genomic location for CSF2RB
Band15 E1|15 37.22 cMStart78,166,707bp[2]
End78,189,921bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • periodontal fiber

  • decidua

  • appendix

  • epithelium of nasopharynx

  • mononuclear cell

  • monocyte

  • bone marrow

  • bone marrow cell

  • testicle
Top expressed in
  • mesenteric lymph nodes

  • granulocyte

  • stroma of bone marrow

  • subcutaneous adipose tissue

  • lactiferous gland

  • tibiofemoral joint

  • muscle of thigh

  • blood

  • spleen

  • Paneth cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1439

12984

Ensembl

ENSG00000100368

ENSMUSG00000071714

UniProt

P32927

P26954

RefSeq (mRNA)

NM_000395

NM_001287389
NM_007781

RefSeq (protein)

NP_000386

NP_001274318
NP_031807

Location (UCSC)Chr 22: 36.91 – 36.94 MbChr 15: 78.17 – 78.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CSF2RB (also known ascytokine receptor common subunit beta) is a common subunit to the followingtype I cytokine receptors:

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000100368Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000071714Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994)."Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF".The EMBO Journal.13 (21):5176–85.doi:10.1002/j.1460-2075.1994.tb06848.x.PMC 395466.PMID 7957082.

External links

[edit]
Chemokine receptor
(GPCRs)
CC
CXC
Other
TNF receptor
1-10
11-20
21-27
JAK-STAT
Type I
γ-chain
β-chain
gp130
IL12RB1
Other
Type II
Ig superfamily
IL 17 family
Enzyme-linked receptor
1–50
51–100
101–150
151–200
201–250
251–300
301–350
Chemokine
CSF
Erythropoietin
G-CSF (CSF3)
GM-CSF (CSF2)
M-CSF (CSF1)
SCF (c-Kit)
Thrombopoietin
Interferon
IFNAR (α/β, I)
IFNGR (γ, II)
IFNLR (λ, III)
  • See IL-28R (IFNLR)here instead.
Interleukin
TGFβ
TNF
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(inhibitors)
JAK1
JAK2
JAK3
TYK2
Others
IL-1
IL-2
IL-3
IL-4
IL-5
IL-6
IL-7
IL-8
  • See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.
IL-9
IL-10
IL-11
IL-12
IL-13
IL-15
IL-17
IL-18
IL-20
IL-21
IL-22
IL-23
IL-27
IL-28
IL-31
IL1RL1
IL1RL2
Others
JAK
Others
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