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COVAX-19 (orSpikoGen) is a recombinant protein-basedCOVID-19 vaccine developed bySouth Australian-based biotech company Vaxine, in collaboration with CinnaGen, a private company with operations inWest Asia. It is underclinical trial in collaboration with theIranian companyCinnaGen.^[3][4][5]

It requires two doses 21 days apart given byintramuscular injection.^[4]

COVAX-19 is a recombinantprotein subunit.^[6]

Vaxine began work on a COVID-19 vaccine in January 2020. After developing a vaccine adjuvant the company decided to focus on a "recombinant protein-based vaccine". A phase 1 human trial started in June 2020. The phase 1 trial involved 40 participants, 30 of whom received the vaccine. The remaining ten participants received a saline placebo.^[7]

Phases 2 and 3 clinical trials of COVAX-19 are being conducted in Iran under a co-operation agreement.^[8] Phase 2 clinical trials started in May 2021 and Phase 3 trials commenced in August 2021. In the phase 2 trials, 400 Iranian volunteers were injected with either a placebo or the first dose of the vaccine. If the studies are successful,Cinnagen will produce the vaccine under the name SpikoGen in Iran.^[7][9]

On 6 October 2021, Iran approved the vaccine for emergency use.^[15]

• COVID-19 vaccine clinical research
• COVID-19 pandemic in Australia
• COVID-19 pandemic in Iran
• Pharmaceuticals in Iran

Scholia has a profile forCOVAX-19(Q107864269).

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