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CMP kinase

From Wikipedia, the free encyclopedia
Enzyme found in humans
CMPK1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1TEV

Identifiers
AliasesCMPK1, CK, CMK, CMPK, UMK, UMP-CMPK, UMPK, cytidine/uridine monophosphate kinase 1
External IDsOMIM:191710;MGI:1913838;HomoloGene:32308;GeneCards:CMPK1;OMA:CMPK1 - orthologs
EC number2.7.4.6
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CMPK1
Genomic location for CMPK1
Band1p33Start47,333,790bp[1]
End47,378,839bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for CMPK1
Genomic location for CMPK1
Band4|4 D1Start114,816,533bp[2]
End114,844,438bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • palpebral conjunctiva

  • parotid gland

  • mucosa of sigmoid colon

  • duodenum

  • rectum

  • epithelium of nasopharynx

  • tibia

  • oral cavity

  • Achilles tendon
Top expressed in
  • saccule

  • otic placode

  • otic vesicle

  • left colon

  • olfactory epithelium

  • gastric mucosa

  • mucous cell of stomach

  • epithelium of stomach

  • crypt of lieberkuhn of small intestine

  • intestinal villus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51727

66588

Ensembl

ENSG00000162368

ENSMUSG00000028719

UniProt

P30085

Q9DBP5

RefSeq (mRNA)

NM_001136140
NM_016308
NM_001366135

NM_025647

RefSeq (protein)

NP_001129612
NP_057392
NP_001353064

NP_079923

Location (UCSC)Chr 1: 47.33 – 47.38 MbChr 4: 114.82 – 114.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UMP-CMP kinase is anenzyme that in humans is encoded by theCMPK1gene.[5][6]

Function

[edit]

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.[6][7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000162368Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028719Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme".Molecular Pharmacology.56 (3):562–9.doi:10.1124/mol.56.3.562.PMID 10462544.S2CID 22945276.
  6. ^abEntrezGene51727
  7. ^Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates".Cancer Research.62 (6):1624–31.PMID 11912132.

External links

[edit]

Further reading

[edit]
PDB gallery
  • 1tev: Crystal structure of the human UMP/CMP kinase in open conformation
    1tev: Crystal structure of the human UMP/CMP kinase in open conformation


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