Chloride intracellular channel protein 6 is aprotein that in humans is encoded by theCLIC6gene.[5][6]
The CLIC6 gene encodes a member of thechloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]
CLIC6 has been shown to formchloride selectiveredox andpH regulatedion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells.[8]
^Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors".Brain Research. Molecular Brain Research.117 (1):47–57.doi:10.1016/S0169-328X(03)00283-3.PMID14499480.
Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, et al. (August 2002). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q".Mammalian Genome.13 (8):456–462.doi:10.1007/s00335-001-2157-0.hdl:11586/196820.PMID12226712.S2CID26059147.
Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, et al. (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression".Cancer Immunity.1: 4.PMID12747765.
Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors".Brain Research. Molecular Brain Research.117 (1):47–57.doi:10.1016/S0169-328X(03)00283-3.PMID14499480.
Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, et al. (November 2003). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12".Gene.320:31–40.doi:10.1016/S0378-1119(03)00830-8.PMID14597386.
