C-type lectin domain family 4 member M is aprotein that in humans is encoded by theCLEC4Mgene.[5] CLEC4M has also been designated asCD299 (cluster of differentiation 299).
This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical toCD209 antigen, anHIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank".Gene.228 (1–2):161–7.doi:10.1016/S0378-1119(99)00004-9.PMID10072769.
Baribaud F, Doms RW, Pöhlmann S (2006). "The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?".Expert Opin. Ther. Targets.6 (4):423–31.doi:10.1517/14728222.6.4.423.PMID12223058.S2CID21541850.
Gattegno L, Ramdani A, Jouault T, et al. (1992). "Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1)".AIDS Res. Hum. Retroviruses.8 (1):27–37.doi:10.1089/aid.1992.8.27.PMID1736938.
Feinberg H, Mitchell DA, Drickamer K, Weis WI (2002). "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR".Science.294 (5549):2163–6.doi:10.1126/science.1066371.PMID11739956.S2CID25046581.
Soilleux EJ, Morris LS, Rushbrook S, et al. (2002). "Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity".Hum. Pathol.33 (6):652–9.doi:10.1053/hupa.2002.124036.PMID12152166.
