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CLCN3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

CLCN3
Identifiers
AliasesCLCN3, CLC3, ClC-3, chloride voltage-gated channel 3, NEDSBA, NEDHYBA
External IDsOMIM:600580;MGI:103555;HomoloGene:20435;GeneCards:CLCN3;OMA:CLCN3 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CLCN3
Genomic location for CLCN3
Band4q33Start169,612,633bp[1]
End169,723,673bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CLCN3
Genomic location for CLCN3
Band8 B3.1|8 30.9 cMStart61,363,423bp[2]
End61,436,334bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of sigmoid colon

  • endothelial cell

  • Brodmann area 46

  • Epithelium of choroid plexus

  • retinal pigment epithelium

  • postcentral gyrus

  • islet of Langerhans

  • parotid gland

  • right ventricle

  • superior vestibular nucleus
Top expressed in
  • Rostral migratory stream

  • mammillary body

  • lateral septal nucleus

  • ventromedial nucleus

  • lateral geniculate nucleus

  • lateral hypothalamus

  • cingulate gyrus

  • anterior amygdaloid area

  • paraventricular nucleus of hypothalamus

  • subiculum
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1182

12725

Ensembl

ENSG00000109572

ENSMUSG00000004319

UniProt

P51790

P51791

RefSeq (mRNA)

NM_001243372
NM_001243374
NM_001829
NM_173872

NM_007711
NM_173873
NM_173874
NM_173876

RefSeq (protein)

NP_001230301
NP_001230303
NP_001820
NP_776297

NP_031737
NP_776298
NP_776299
NP_776301

Location (UCSC)Chr 4: 169.61 – 169.72 MbChr 8: 61.36 – 61.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

2Cl-/H+ exchanger 3 is aprotein that in humans is encoded by theCLCN3gene.[5]

Interactions

[edit]

CLCN3 has been shown tointeract withPDZK1 and TMEM9.<ref name=pmid12471024>Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR (Feb 2003)."The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins".J. Biol. Chem.278 (8):6440–9.doi:10.1074/jbc.M211050200.PMID 12471024.<pmid40169677>Planells-Cases R, Vorobeva V, Kar S, Schmitt F, Schulte U, Schrecker M, Hite R, Fakler B, Jentsch T (2025)."Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity".Nature Communications.16:1–17.doi:10.1038/s41467-025-58546-3.PMC 11962092.PMID 40169677.

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000109572Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000004319Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: CLCN3 chloride channel 3".

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl:Chloride channel
H+:Proton channel
M+:CNG cation channel
M+:TRP cation channel
H2O (+solutes):Porin
Cytoplasm:Gap junction
By gating mechanism
Ion channel class
see alsodisorders


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