Chloride channel accessory 1 is aprotein that in humans is encoded by theCLCA1gene.[5][6]
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zincmetalloprotease.[7]
^Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels".Proteins.63 (3):424–39.doi:10.1002/prot.20887.PMID16470849.S2CID40041491.
Loewen ME, Bekar LK, Gabriel SE, et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells".Biochem. Biophys. Res. Commun.298 (4):531–6.doi:10.1016/S0006-291X(02)02498-1.PMID12408984.
Zhou Y, Shapiro M, Dong Q, et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction".Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–65, discussion 165–70,277–82.doi:10.1002/0470860790.ch10.ISBN9780470844786.PMID12568493.
Ritzka M, Stanke F, Jansen S, et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis".Hum. Genet.115 (6):483–91.doi:10.1007/s00439-004-1190-y.PMID15490240.S2CID12935280.
Jeong SM, Park HK, Yoon IS, et al. (2005). "Cloning and expression of Ca2+-activated chloride channel from rat brain".Biochem. Biophys. Res. Commun.334 (2):569–76.doi:10.1016/j.bbrc.2005.06.122.PMID16023076.
