Neuronal acetylcholine receptor subunit alpha-1, also known asnAChRα1, is aprotein that in humans is encoded by theCHRNA1gene.[5] The protein encoded by this gene is a subunit of certainnicotinic acetylcholine receptors (nAchR).
The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
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