Cadherin EGF LAG seven-pass G-type receptor 2 is aprotein that in humans is encoded by theCELSR2gene.[5][6]
The protein encoded by this gene is a member of theflamingo subfamily, part of thecadherin superfamily. The flamingo subfamily consists of nonclassic-typecadherins; a subpopulation that does not interact withcatenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting ashomophilic binding regions and the EGF-like domains involved incell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening".Genomics.51 (1):27–34.doi:10.1006/geno.1998.5341.PMID9693030.
