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CDKL2

From Wikipedia, the free encyclopedia
Protein-coding gene in humans

CDKL2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

4AAA,4BBM

Identifiers
AliasesCDKL2, KKIAMRE, P56, cyclin dependent kinase like 2
External IDsOMIM:603442;MGI:1858227;HomoloGene:55793;GeneCards:CDKL2;OMA:CDKL2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CDKL2
Genomic location for CDKL2
Band4q21.1Start75,576,496bp[1]
End75,630,716bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CDKL2
Genomic location for CDKL2
Band5|5 E2Start92,006,074bp[2]
End92,043,883bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • Brodmann area 23

  • middle temporal gyrus

  • postcentral gyrus

  • superior frontal gyrus

  • testicle

  • primary visual cortex

  • entorhinal cortex

  • lower lobe of lung

  • prefrontal cortex
Top expressed in
  • barrel cortex

  • lumbar spinal ganglion

  • spermatocyte

  • facial motor nucleus

  • seminiferous tubule

  • olfactory epithelium

  • spermatid

  • vestibular sensory epithelium

  • zygote

  • Epithelium of choroid plexus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8999

53886

Ensembl

ENSG00000138769

ENSMUSG00000029403

UniProt

Q92772

Q9QUK0

RefSeq (mRNA)

NM_003948
NM_001330724

NM_001276315
NM_016912
NM_177270

RefSeq (protein)

NP_001317653
NP_003939

NP_001263244
NP_058608
NP_796244

Location (UCSC)Chr 4: 75.58 – 75.63 MbChr 5: 92.01 – 92.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase-like 2 is anenzyme that in humans is encoded by theCDKL2gene.[5][6]

Thisgene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in thecytoplasm, with lower levels in thenucleus.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000138769 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000029403 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE".Oncogene.13 (12):2563–2574.PMID 9000130.
  6. ^ab"Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

Further reading

[edit]

External links

[edit]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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