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CDK12

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From Wikipedia, the free encyclopedia

Protein kinase gene

CDK12

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
4CXA,4NST,4UN0,5ACB

Identifiers

Aliases

CDK12, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, cyclin dependent kinase 12

External IDs

OMIM:615514;MGI:1098802;HomoloGene:128632;GeneCards:CDK12;OMA:CDK12 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q12	Start	39,461,486bp^[1]
Band	17q12	End	39,564,907bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 D\|11 61.75 cM	Start	98,093,885bp^[2]
Band	11 D\|11 61.75 cM	End	98,169,330bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

sural nerve

secondary oocyte

epithelium of colon

ganglionic eminence

gastric mucosa

ventricular zone

Achilles tendon

skin of leg

tonsil

Top expressed in

zygote

secondary oocyte

ascending aorta

tail of embryo

Rostral migratory stream

aortic valve

genital tubercle

granulocyte

spermatocyte

primary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding RNA polymerase II CTD heptapeptide repeat kinase activity ATP binding cyclin binding cyclin-dependent protein serine/threonine kinase activity transcription factor binding protein kinase binding
Cellular component	nuclear speck nuclear cyclin-dependent protein kinase holoenzyme complex cyclin K-CDK12 complex nucleus nucleoplasm fibrillar center chromosome cyclin/CDK positive transcription elongation factor complex cyclin-dependent protein kinase holoenzyme complex
Biological process	phosphorylation of RNA polymerase II C-terminal domain phosphorylation mRNA processing regulation of cell cycle protein phosphorylation regulation of RNA splicing RNA splicing protein autophosphorylation regulation of MAP kinase activity transcription elongation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II negative regulation of stem cell differentiation positive regulation of transcription elongation from RNA polymerase II promoter
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


51755


69131

Ensembl


ENSG00000167258


ENSMUSG00000003119

UniProt


Q9NYV4


Q14AX6

RefSeq (mRNA)


NM_015083 NM_016507


NM_001109626 NM_001109628 NM_026952

RefSeq (protein)


NP_055898 NP_057591


NP_001103096 NP_001103098 NP_081228

Location (UCSC)

Chr 17: 39.46 – 39.56 Mb

Chr 11: 98.09 – 98.17 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CDK12 cyclin-dependent kinase 12 is aprotein kinase that in humans is encoded by theCDK12gene.^[5]^[6]^[7] Thisenzyme is a member ofcyclin-dependent kinase protein family.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000167258 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000003119 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999)."Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.5 (6):355–64.doi:10.1093/dnares/5.6.355.PMID 10048485.
^Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles".J Cell Sci.114 (Pt 14):2591–603.doi:10.1242/jcs.114.14.2591.PMID 11683387.
^"Entrez Gene: CDK12 cyclin-dependent kinase 12".

External links

[edit]

HumanCDK12 genome location andCDK12 gene details page in theUCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003)."Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones".DNA Res.9 (3):99–106.doi:10.1093/dnares/9.3.99.PMID 12168954.
Wissing J, Jänsch L, Nimtz M, et al. (2007)."Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry"(PDF).Mol. Cell. Proteomics.6 (3):537–47.doi:10.1074/mcp.T600062-MCP200.PMID 17192257.S2CID 40974821.
Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127 (3):635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.S2CID 7827573.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".Nat. Biotechnol.24 (10):1285–92.doi:10.1038/nbt1240.PMID 16964243.S2CID 14294292.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proc. Natl. Acad. Sci. U.S.A.101 (33):12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC 514446.PMID 15302935.
Colland F, Jacq X, Trouplin V, et al. (2004)."Functional proteomics mapping of a human signaling pathway".Genome Res.14 (7):1324–32.doi:10.1101/gr.2334104.PMC 442148.PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

Cell cycle proteins

Cyclin

A (A1,A2)
B (B1,B2, B3)
D (D1,D2,D3)
E (E1,E2)

CDK

CDK inhibitor

INK4a/ARF (p14arf/p16,p15,p18,p19)
cip/kip (p21,p27,p57)

P53 p63 p73 family

Other

Phases and
checkpoints

Interphase	G₁ phase S phase G₂ phase
M phase	Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis
Cell cycle checkpoints	Restriction point Spindle checkpoint Postreplication checkpoint
Other cellular phases	Apoptosis G₀ phase Meiosis

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