This gene is a classicalcadherin from the cadherin superfamily. The encoded protein is a calcium-dependentcell-cell adhesionglycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[7]
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^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
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^Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3".Cytogenet Cell Genet.86 (1):26–7.doi:10.1159/000015423.PMID10516427.S2CID27578498.
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