Protein-coding gene in humans
T-cell surface glycoprotein CD8 alpha chain (C luster ofD ifferentiation8a ), is a protein encoded byCD8A gene .[ 5]
TheCD8 protein is a cell surfaceglycoprotein found on mostcytotoxic T lymphocytes that mediates efficientcell-cell interactions within theimmune system . The CD8, acting as acoreceptor , and theT-cell receptor on the T lymphocyte recognizeantigen displayed by anantigen-presenting cell (APC) in the context ofclass I MHC molecules. The functional coreceptor is either ahomodimer composed of two alpha chains, or aheterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significanthomology tovariable domain ofimmunoglobulin light chains . This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, onemembrane associated and onesecreted , have been identified.[ 5]
CD8A has been shown tointeract with:
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PDB gallery
1akj : COMPLEX OF THE HUMAN MHC CLASS I GLYCOPROTEIN HLA-A2 AND THE T CELL CORECEPTOR CD8
1cd8 : CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION
2hp4 : Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor
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This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
