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Integrin alpha 4

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From Wikipedia, the free encyclopedia

(Redirected fromCD49d)

Mammalian protein found in Homo sapiens

ITGA4

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
4HKC,3V4P,3V4V,5FPI,5C7Z

Identifiers

Aliases

ITGA4, CD49D, IA4, integrin subunit alpha 4

External IDs

OMIM:192975;MGI:96603;HomoloGene:37364;GeneCards:ITGA4;OMA:ITGA4 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q31.3	Start	181,457,202bp^[1]
Band	2q31.3	End	181,538,940bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 C3\|2 47.38 cM	Start	79,085,770bp^[2]
Band	2 C3\|2 47.38 cM	End	79,163,467bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

bone marrow cell

granulocyte

appendix

blood

lymph node

spleen

trabecular bone

secondary oocyte

epithelium of colon

Top expressed in

blood

spleen

lumbar spinal ganglion

mesenteric lymph nodes

internal carotid artery

external carotid artery

muscle layer of urethra

thymus

granulocyte

human fetus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding protein antigen binding metal ion binding antigen binding fibronectin binding cell adhesion molecule binding coreceptor activity C-X3-C chemokine binding protein heterodimerization activity
Cellular component	extracellular exosome integral component of membrane membrane focal adhesion cell surface integrin alpha4-beta7 complex integrin complex plasma membrane growth cone soma protein-containing complex
Biological process	endodermal cell differentiation B cell differentiation positive regulation of T cell migration extracellular matrix organization heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading cellular response to cytokine stimulus cell-matrix adhesion involved in ameboidal cell migration cell-matrix adhesion leukocyte tethering or rolling diapedesis regulation of immune response integrin-mediated signaling pathway leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte migration import into cell leukocyte cell-cell adhesion negative regulation of protein homodimerization activity clathrin-dependent extracellular exosome endocytosis cell adhesion receptor clustering cell-cell adhesion mediated by integrin axonogenesis involved in innervation cell-cell adhesion in response to extracellular stimulus cellular response to amyloid-beta positive regulation of vascular endothelial cell proliferation neuron projection extension positive regulation of endothelial cell apoptotic process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3676


16401

Ensembl


ENSG00000115232


ENSMUSG00000027009

UniProt


P13612


Q00651

RefSeq (mRNA)


NM_000885 NM_001316312


NM_010576

RefSeq (protein)


NP_000876 NP_001303241


NP_034706

Location (UCSC)

Chr 2: 181.46 – 181.54 Mb

Chr 2: 79.09 – 79.16 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CD49d is anintegrin alpha subunit. It makes up half of the α4β1lymphocyte homing receptor.

Function

[edit]

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.^[5]

Interactions

[edit]

CD49d has been shown tointeract withLGALS8^[6] andPaxillin.^[7]^[8]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000115232 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000027009 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)".
^Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis".J. Cell Sci.113 (Pt 13):2385–97.doi:10.1242/jcs.113.13.2385.PMID 10852818.
^Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001)."Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding".J. Biol. Chem.276 (44):40903–9.doi:10.1074/jbc.M102665200.PMID 11533025.
^Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002)."A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration".J. Biol. Chem.277 (23):20887–94.doi:10.1074/jbc.M110928200.PMID 11919182.

External links

[edit]

CD49d+antigen at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
ITGA4 Info with links in theCell Migration Gateway Archived 2014-12-11 at theWayback Machine
HumanITGA4 genome location andITGA4 gene details page in theUCSC Genome Browser.
Overview of all the structural information available in thePDB forUniProt:P13612 (Human Integrin alpha-4) at thePDBe-KB.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Integrins

Alpha

Beta

Dimers

Cytoadhesin receptor:	Integrin alpha6beta4 Glycoprotein IIb/IIIa ITGA2B+ITGB3
Fibrinogen receptor:	Macrophage-1 antigen CD11b+CD18
Fibronectin receptor:	Integrin alpha2beta1 Integrin alpha4beta1 Integrin alpha5beta1
Leukocyte-adhesion receptor:	LFA-1 CD11a+CD18 Macrophage-1 antigen CD11b+CD18 Integrin alphaXbeta2 CD11c+CD18
Very late antigen receptor:	Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1 VLA-4 CD49d+CD29 Alpha-5 beta-1 Integrin alpha6beta1
Vitronectin receptor:	Alpha-v beta-3 Alpha-v beta-5