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This receptor is expressed by activated, but not by resting,T andB cells.TRAF2 andTRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation ofNF-kappaB.[6] It is a positive regulator ofapoptosis,[7] and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.[citation needed] Twoalternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[5]
^Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (Nov 2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]".Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology (in Chinese).34 (11):711–5.PMID16536313.
^Gorczyca W, Tsang P, Liu Z, Wu CD, Dong HY, Goldstein M, Cohen P, Gangi M, Weisberger J (Feb 2003). "CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis".International Journal of Oncology.22 (2):319–24.doi:10.3892/ijo.22.2.319.PMID12527929.
Schneider C, Hübinger G (Jul 2002). "Pleiotropic signal transduction mediated by human CD30: a member of the tumor necrosis factor receptor (TNFR) family".Leukemia & Lymphoma.43 (7):1355–66.doi:10.1080/10428190290033288.PMID12389614.S2CID12699308.
Horie R, Higashihara M, Watanabe T (Jan 2003). "Hodgkin's lymphoma and CD30 signal transduction".International Journal of Hematology.77 (1):37–47.doi:10.1007/BF02982601.PMID12568298.S2CID24727080.
Dürkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H (Feb 1992). "Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease".Cell.68 (3):421–7.doi:10.1016/0092-8674(92)90180-K.PMID1310894.S2CID7999537.
Fonatsch C, Latza U, Dürkop H, Rieder H, Stein H (Nov 1992). "Assignment of the human CD30 (Ki-1) gene to 1p36".Genomics.14 (3):825–6.doi:10.1016/S0888-7543(05)80203-4.PMID1330892.
Josimovic-Alasevic O, Dürkop H, Schwarting R, Backé E, Stein H, Diamantstein T (Jan 1989). "Ki-1 (CD30) antigen is released by Ki-1-positive tumor cells in vitro and in vivo. I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme-linked immunosorbent assay".European Journal of Immunology.19 (1):157–62.doi:10.1002/eji.1830190125.PMID2537734.S2CID29049745.
Stein H, Gerdes J, Schwab U, Lemke H, Mason DY, Ziegler A, Schienle W, Diehl V (Oct 1982). "Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population".International Journal of Cancer.30 (4):445–59.doi:10.1002/ijc.2910300411.PMID6754630.S2CID24167082.
Jung W, Krueger S, Renner C, Gause A, Sahin U, Trümper L, Pfreundschuh M (Dec 1994). "Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources".Molecular Immunology.31 (17):1329–34.doi:10.1016/0161-5890(94)90051-5.PMID7527901.
Shiota M, Fujimoto J, Semba T, Satoh H, Yamamoto T, Mori S (Jun 1994). "Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3".Oncogene.9 (6):1567–74.PMID8183550.
Boucher LM, Marengère LE, Lu Y, Thukral S, Mak TW (Apr 1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily".Biochemical and Biophysical Research Communications.233 (3):592–600.doi:10.1006/bbrc.1997.6509.PMID9168896.
Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J (Jan 1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)".Gene.207 (2):135–40.doi:10.1016/S0378-1119(97)00616-1.PMID9511754.
