This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites,SH3 domains, and aproline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes tomembrane ruffles,lipid rafts, and the leading edges of cells. It is implicated in dynamicactin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.[6]
^Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites".J. Cell Sci.117 (Pt 12):2557–68.doi:10.1242/jcs.01148.PMID15128873.S2CID14083271.
^abCormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (Feb 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl".Traffic.4 (2):97–112.doi:10.1034/j.1600-0854.2003.40205.x.PMID12559036.S2CID38612642.
Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y (2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl".Traffic.4 (2):97–112.doi:10.1034/j.1600-0854.2003.40205.x.PMID12559036.S2CID38612642.
Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites".J. Cell Sci.117 (Pt 12):2557–68.doi:10.1242/jcs.01148.PMID15128873.S2CID14083271.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".Nat. Biotechnol.23 (1):94–101.doi:10.1038/nbt1046.PMID15592455.S2CID7200157.
