This article is about a molecule in immunology and is not to be confused with CD2, the simplified chemical formula ofdeuteratedpolyethylene.
CD2 (cluster of differentiation 2) is acell adhesion molecule found on the surface ofT cells andnatural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,[5] LFA-3 receptor, erythrocyte receptor and rosette receptor.[6]
It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, orCD48 in rodents, which are expressed on the surfaces of other cells.[7]
In addition to its adhesive properties, CD2 also acts as aco-stimulatory molecule on T and NK cells.[8]
CD2 is a specific marker for T cells and NK cells, and can therefore be used inimmunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T celllymphomas andleukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cellneoplasms.[9]
^Wilkins AL, Yang W, Yang JJ (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design".Curr Protein Pept Sci.4 (5):367–73.doi:10.2174/1389203033487063.PMID14529530.
^abYang JJ, Ye Y, Carroll A, Yang W, Lee HW (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation".Curr Protein Pept Sci.2 (1):1–17.doi:10.2174/1389203013381251.PMID12369898.
^Leong, Anthony S-Y, Cooper, Kumarason, Leong, F Joel W-M (2003).Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 61.ISBN978-1-84110-100-2.
Sayre PH, Reinherz EL (1989). "Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review".Scand. J. Rheumatol. Suppl.76:131–44.doi:10.3109/03009748809102963.PMID2471997.
Rouleau M, Mollereau B, Bernard A, Metivier D, Rosenthal-Allieri MA, Charpentier B, Senik A (1997). "CD2 induced apoptosis of peripheral T cells".Transplant. Proc.29 (5):2377–8.doi:10.1016/S0041-1345(97)00410-7.PMID9270771.
Yang JJ, Ye Y, Carroll A, Yang W, Lee HW (2002). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation".Curr. Protein Pept. Sci.2 (1):1–17.doi:10.2174/1389203013381251.PMID12369898.
Luzzati AL, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope".Immunol. Lett.33 (3):307–14.doi:10.1016/0165-2478(92)90078-3.PMID1385321.
Luzzati AL, Pugliese O, Giacomini E, Giordani L, Quintieri F, Hraba T, Mach O, Krchnák V, Vágner J (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV".Folia Biol. (Praha).36 (1):71–7.PMID2111780.
Leca G, Boumsell L, Fabbi M, Reinherz EL, Kanellopoulos JM (1986). "The sheep erythrocyte receptor and both alpha and beta chains of the human T-lymphocyte antigen receptor bind the mitogenic lectin (phytohaemagglutinin) from Phaseolus vulgaris".Scand. J. Immunol.23 (5):535–44.doi:10.1111/j.1365-3083.1986.tb01985.x.PMID3085210.S2CID84246845.
