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CD164

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From Wikipedia, the free encyclopedia

Protein found in humans

CD164

Identifiers

Aliases

CD164, MGC-24, MUC-24, endolyn, DFNA66, CD164 molecule, MGC-24v

External IDs

OMIM:603356;MGI:1859568;HomoloGene:38129;GeneCards:CD164;OMA:CD164 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q21	Start	109,366,514bp^[1]
Band	6q21	End	109,382,467bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 B2\|10 22.46 cM	Start	41,395,410bp^[2]
Band	10 B2\|10 22.46 cM	End	41,407,044bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of sigmoid colon

bronchial epithelial cell

kidney tubule

secondary oocyte

skin of hip

lactiferous duct

rectum

epithelium of nasopharynx

glomerulus

skin of thigh

Top expressed in

parotid gland

submandibular gland

epithelium of lens

Epithelium of choroid plexus

iris

retinal pigment epithelium

lacrimal gland

vestibular membrane of cochlear duct

cornea

islet of Langerhans

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding
Cellular component	integral component of membrane extracellular region lysosomal membrane endosome plasma membrane lysosome integral component of plasma membrane endosome membrane membrane cytoplasmic vesicle
Biological process	multicellular organism development negative regulation of cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion muscle organ development immune response signal transduction negative regulation of cell population proliferation hemopoiesis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


8763


53599

Ensembl


ENSG00000135535


ENSMUSG00000019818

UniProt


Q04900


Q9R0L9

RefSeq (mRNA)

NM_006016 NM_001142401 NM_001142402 NM_001142403 NM_001142404
NM_001346500


NM_016898

RefSeq (protein)

NP_001135873 NP_001135874 NP_001135875 NP_001135876 NP_001333429
NP_006007


NP_058594

Location (UCSC)

Chr 6: 109.37 – 109.38 Mb

Chr 10: 41.4 – 41.41 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sialomucin core protein 24 also known asendolyn orCD164 (cluster of differentiation 164) is aprotein that in humans is encoded by theCD164gene.^[5]^[6] CD164 functions as acell adhesion molecule.

Sialomucins are a heterogeneous group of secreted or membrane-associatedmucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000135535 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000019818 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bWatt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21".Blood.92 (3):849–66.doi:10.1182/blood.V92.3.849.PMID 9680353.
^Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis".Blood.92 (8):2613–28.doi:10.1182/blood.V92.8.2613.PMID 9763543.

External links

[edit]

CD164+Antigen at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
HumanCD164 genome location andCD164 gene details page in theUCSC Genome Browser.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Membrane proteins:cell adhesion molecules

Calcium-independent

IgSF CAM	N-CAM (Myelin protein zero) ICAM (1,5) VCAM-1 PE-CAM L1 family L1-CAM NRCAM NFASC CHL1 Nectin PVRL1 PVRL2 PVRL3 CADM1 CADM3 CD155
Integrins	LFA-1 (CD11a+CD18) Integrin alphaXbeta2 (CD11c+CD18) Macrophage-1 antigen (CD11b+CD18) VLA-4 (CD49d+CD29) Glycoprotein IIb/IIIa (ITGA2B+ITGB3)

Calcium-dependent

Cadherins

Classical	CDH1 CDH2 CDH3
Desmosomal	Desmoglein (DSG1,DSG2,DSG3,DSG4) Desmocollin (DSC1,DSC2,DSC3)
Protocadherin	PCDH1 PCDH15 PCDH19
Unconventional/ungrouped	T-cadherin CDH4 CDH5 CDH6 CDH8 CDH11 CDH12 CDH15 CDH16 CDH17 CDH9 CDH10

Selectins

Other

Protein,glycoconjugate:glycoproteins andglycopeptides

Mucoproteins

Mucin	CD43 CD164 MUC1 MUC2 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC20
Other	Haptoglobin Intrinsic factor Orosomucoid Peptidoglycan Phytohaemagglutinin Ovomucin

Proteoglycans

CS/DS	Decorin Biglycan Versican
HS/CS	Testican Perlecan
CS	Chondroitin sulfate proteoglycans:Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5 Platelet factor 4 Structural maintenance of chromosomes 3
KS	Fibromodulin Lumican Keratocan
HS	Syndecan 1

Other

Thismembrane protein–related article is astub. You can help Wikipedia byexpanding it.

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