Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

CD120

From Wikipedia, the free encyclopedia
Protein family
tumor necrosis factor receptor superfamily, member 1A
Identifiers
SymbolTNFRSF1A
Alt. symbolsCD120a, TNFR1
NCBI gene7132
HGNC11916
OMIM191190
RefSeqNM_001065
UniProtP19438
Other data
LocusChr. 12p13.2
Search for
StructuresSwiss-model
DomainsInterPro
tumor necrosis factor receptor superfamily, member 1B
Identifiers
SymbolTNFRSF1B
Alt. symbolsCD120a, TNFR2
NCBI gene7133
HGNC11917
OMIM191191
RefSeqNM_001066
UniProtP20333
Other data
LocusChr. 1p36.22
Search for
StructuresSwiss-model
DomainsInterPro

CD120 (Cluster ofDifferentiation 120) can refer to two members of thetumor necrosis factor receptor superfamily:tumor necrosis factor receptor 1 (TNFR1) andtumor necrosis factor receptor 2 (TNFR2).[1][2]

Receptor subtypes

[edit]

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a - TNFR1 - TNFR superfamily member 1A
  • CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]

Signaling pathway

[edit]
Signaling pathway ofTNF-R1. Dashed grey lines represent multiple steps

See also

[edit]

References

[edit]
  1. ^Locksley RM, Killeen N, Lenardo MJ (2001)."The TNF and TNF receptor superfamilies: integrating mammalian biology".Cell.104 (4):487–501.doi:10.1016/S0092-8674(01)00237-9.PMID 11239407.S2CID 7657797.
  2. ^Hehlgans T, Pfeffer K (2005)."The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games".Immunology.115 (1):1–20.doi:10.1111/j.1365-2567.2005.02143.x.PMC 1782125.PMID 15819693.
  3. ^Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009)."The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior".Psychopharmacology.201 (4):549–56.doi:10.1007/s00213-008-1331-4.PMC 2711641.PMID 18825372.
  4. ^McCoy MK, Tansey MG (2008)."TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease".J Neuroinflammation.5 (1): 45.doi:10.1186/1742-2094-5-45.PMC 2577641.PMID 18925972.
  5. ^Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor".Bipolar Disord.11 (7):726–34.doi:10.1111/j.1399-5618.2009.00757.x.hdl:10852/34620.PMID 19839997.

External links

[edit]
1–50
51–100
101–150
151–200
201–250
251–300
301–350
Chemokine receptor
(GPCRs)
CC
CXC
Other
TNF receptor
1-10
11-20
21-27
JAK-STAT
Type I
γ-chain
β-chain
gp130
IL12RB1
Other
Type II
Ig superfamily
IL 17 family
Enzyme-linked receptor
Chemokine
CSF
Erythropoietin
G-CSF (CSF3)
GM-CSF (CSF2)
M-CSF (CSF1)
SCF (c-Kit)
Thrombopoietin
Interferon
IFNAR (α/β, I)
IFNGR (γ, II)
IFNLR (λ, III)
  • See IL-28R (IFNLR)here instead.
Interleukin
TGFβ
TNF
Others
JAK
(inhibitors)
JAK1
JAK2
JAK3
TYK2
Others
Retrieved from "https://en.wikipedia.org/w/index.php?title=CD120&oldid=1188049587"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp