Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

CAR-302,282

From Wikipedia, the free encyclopedia
Delirant drug
Pharmaceutical compound
CAR-302,282
Identifiers
  • (1-methylpiperidin-4-yl) 2-hydroxy-5-methyl-2-phenylhex-5-en-3-ynoate
CAS Number
PubChemCID
ChemSpider
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H23NO3
Molar mass313.397 g·mol−1
3D model (JSmol)
  • CC(=C)C#CC(C1=CC=CC=C1)(C(=O)OC2CCN(CC2)C)O
  • InChI=1S/C19H23NO3/c1-15(2)9-12-19(22,16-7-5-4-6-8-16)18(21)23-17-10-13-20(3)14-11-17/h4-8,17,22H,1,10-11,13-14H2,2-3H3
  • Key:HNFSQQPBCHYZKE-UHFFFAOYSA-N

CAR-302,282 (302282,NSC-263548,α-(3-Methylbut-1-yn-3-enyl)mandelic acid 1-methyl-4-piperidyl ester) is ananticholinergicdeliriant drug,[1][2] invented under contract toEdgewood Arsenal in the 1960s. It is a potent incapacitating agent with an ED50 of 1.2μg/kg and a high central to peripheral effects ratio, and a relatively short duration of action compared to other similar drugs of around 6-10 hours. Despite its favorable properties it was relatively little researched compared to more high profile compounds from the series such asEA-3167 andEA-3580.[3]

See also

[edit]

References

[edit]
  1. ^Baumgold J, Abood LG, Aronstam R (March 1977). "Studies on the relationship of binding affinity to psychoactive and anticholingergic potency of a group of psychotomimetic glycolates".Brain Research.124 (2):331–40.doi:10.1016/0006-8993(77)90889-7.PMID 843950.S2CID 35326203.
  2. ^US 4465834, Baum BM, Stange H, "Anticholinergic Drugs.", issued 14 August 1984 
  3. ^Ketchum JS (2006).Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc. p. 320-326.ISBN 978-1-4243-0080-8.


Psychedelics
(5-HT2AR agonists)
  • For a full list of serotonergic psychedelics, see the navboxhere and the listhere instead.
Dissociatives
(NMDARantagonists)
Arylcyclo‐
hexylamines
Adamantanes
Diarylethylamines
Morphinans
Others
Deliriants
(mAChRantagonists)
Cannabinoids
(CB1R agonists)
Natural
Synthetic
AM-x
CPx
HU-x
JWH-x
Misc.
  •  For a full list of cannabinoids, see the navboxhere and the listhere instead.
κORagonists
GABAARagonists
Inhalants
(mixedMoATooltip mechanism of action)
Others
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)


Stub icon

Thishallucinogen-related article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=CAR-302,282&oldid=1148717576"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp